Unrecognized Prediabetes Is Highly Prevalent in Men With Erectile Dysfunction–Results From a Cross-Sectional Study

Luca Boeri, Paolo Capogrosso, Filippo Pederzoli, Eugenio Ventimiglia, Nicola Frego, Francesco Chierigo, Emanuele Montanari, Francesco Montorsi, Andrea Salonia

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: The association between prediabetes (PreDM) and erectile dysfunction (ED) has been analyzed scantly. Aim: To assess the association between PreDM and erectile function (EF) in a cohort of white European men with ED. Methods: Demographic, clinical, and laboratory data from 372 consecutive men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). Patients were invited to complete the International Index of Erectile Function (IIEF)-EF domain questionnaire. The EF domain was categorized according to Cappelleri's criteria. Men were defined as having PreDM according to the criteria defined by the American Diabetes Association (2015). Descriptive statistics and logistic regression models tested the association between clinical variables and PreDM status and severe ED. Main Outcome Measures: We assessed the prevalence of PreDM in our cohort of men with ED and the potential association of PreDM and sexual health within the same cohort. Results: Of 372 men, +PreDM was found in 86 (23.1%) patients. Men with +PreDM had lower total testosterone (tT), higher triglycerides, and higher total cholesterol values (all P <.03) than those without PreDM. Likewise, +PreDM patients had a higher rate of CCI ≥1 (P =.03) and more frequently had severe ED (P =.013) compared with –PreDM. Age (OR 1.03; P =.01); lower tT (OR 0.81; P =.02); and severe ED (OR 3.37; P =.004) were associated with +PreDM status, after accounting for BMI, CCI, alcohol consumption, and cigarette smoking. Similarly, age (OR 1.02; P =.02) and +PreDM (OR 2.02; P =.02) were associated with severe ED, after accounting for other clinical variables. Clinical Implications: Identifying +PreDM status in ED men is clinically relevant in order to adopt preventive strategies to attempt and reduce risk of developing DM and subsequent cardiovascular diseases. Strengths & Limitations: To our knowledge, this is the first study evaluating the prevalence of unrecognized PreDM and the association of PreDM and ED severity in a real-life setting. Limitations are the retrospective nature of the cross-sectional study and the lack of haemodynamic parameters for every patient. Conclusions: 1 in 5 men seeking medical help for new-onset ED showed glucose values suggestive for unrecognized PreDM and +PreDM status was associated with worse hormonal and metabolic profiles, along with a higher risk of severe ED than −PreDM. Boeri L, Capogrosso P, Perderzoli F, et al. Unrecognized prediabetes is highly prevalent in men with erectile dysfunction–results from a cross-sectional study. J Sex Med 2018;15:1117–1124.

Original languageEnglish
Pages (from-to)1117-1124
Number of pages8
JournalJournal of Sexual Medicine
Volume15
Issue number8
DOIs
Publication statusPublished - Aug 1 2018

Fingerprint

Prediabetic State
Erectile Dysfunction
Cross-Sectional Studies
Comorbidity
Testosterone
Logistic Models
Metabolome
Reproductive Health
Alcohol Drinking
Triglycerides
Cardiovascular Diseases
Hemodynamics
Smoking
Cholesterol
Demography
Outcome Assessment (Health Care)

Keywords

  • Diabetes
  • Erectile Dysfunction
  • Prediabetes
  • Prevention
  • Risk Factors
  • Testosterone

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Urology

Cite this

Unrecognized Prediabetes Is Highly Prevalent in Men With Erectile Dysfunction–Results From a Cross-Sectional Study. / Boeri, Luca; Capogrosso, Paolo; Pederzoli, Filippo; Ventimiglia, Eugenio; Frego, Nicola; Chierigo, Francesco; Montanari, Emanuele; Montorsi, Francesco; Salonia, Andrea.

In: Journal of Sexual Medicine, Vol. 15, No. 8, 01.08.2018, p. 1117-1124.

Research output: Contribution to journalArticle

Boeri, Luca ; Capogrosso, Paolo ; Pederzoli, Filippo ; Ventimiglia, Eugenio ; Frego, Nicola ; Chierigo, Francesco ; Montanari, Emanuele ; Montorsi, Francesco ; Salonia, Andrea. / Unrecognized Prediabetes Is Highly Prevalent in Men With Erectile Dysfunction–Results From a Cross-Sectional Study. In: Journal of Sexual Medicine. 2018 ; Vol. 15, No. 8. pp. 1117-1124.
@article{e98c41b5328546718f09f18856e6325c,
title = "Unrecognized Prediabetes Is Highly Prevalent in Men With Erectile Dysfunction–Results From a Cross-Sectional Study",
abstract = "Introduction: The association between prediabetes (PreDM) and erectile dysfunction (ED) has been analyzed scantly. Aim: To assess the association between PreDM and erectile function (EF) in a cohort of white European men with ED. Methods: Demographic, clinical, and laboratory data from 372 consecutive men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). Patients were invited to complete the International Index of Erectile Function (IIEF)-EF domain questionnaire. The EF domain was categorized according to Cappelleri's criteria. Men were defined as having PreDM according to the criteria defined by the American Diabetes Association (2015). Descriptive statistics and logistic regression models tested the association between clinical variables and PreDM status and severe ED. Main Outcome Measures: We assessed the prevalence of PreDM in our cohort of men with ED and the potential association of PreDM and sexual health within the same cohort. Results: Of 372 men, +PreDM was found in 86 (23.1{\%}) patients. Men with +PreDM had lower total testosterone (tT), higher triglycerides, and higher total cholesterol values (all P <.03) than those without PreDM. Likewise, +PreDM patients had a higher rate of CCI ≥1 (P =.03) and more frequently had severe ED (P =.013) compared with –PreDM. Age (OR 1.03; P =.01); lower tT (OR 0.81; P =.02); and severe ED (OR 3.37; P =.004) were associated with +PreDM status, after accounting for BMI, CCI, alcohol consumption, and cigarette smoking. Similarly, age (OR 1.02; P =.02) and +PreDM (OR 2.02; P =.02) were associated with severe ED, after accounting for other clinical variables. Clinical Implications: Identifying +PreDM status in ED men is clinically relevant in order to adopt preventive strategies to attempt and reduce risk of developing DM and subsequent cardiovascular diseases. Strengths & Limitations: To our knowledge, this is the first study evaluating the prevalence of unrecognized PreDM and the association of PreDM and ED severity in a real-life setting. Limitations are the retrospective nature of the cross-sectional study and the lack of haemodynamic parameters for every patient. Conclusions: 1 in 5 men seeking medical help for new-onset ED showed glucose values suggestive for unrecognized PreDM and +PreDM status was associated with worse hormonal and metabolic profiles, along with a higher risk of severe ED than −PreDM. Boeri L, Capogrosso P, Perderzoli F, et al. Unrecognized prediabetes is highly prevalent in men with erectile dysfunction–results from a cross-sectional study. J Sex Med 2018;15:1117–1124.",
keywords = "Diabetes, Erectile Dysfunction, Prediabetes, Prevention, Risk Factors, Testosterone",
author = "Luca Boeri and Paolo Capogrosso and Filippo Pederzoli and Eugenio Ventimiglia and Nicola Frego and Francesco Chierigo and Emanuele Montanari and Francesco Montorsi and Andrea Salonia",
year = "2018",
month = "8",
day = "1",
doi = "10.1016/j.jsxm.2018.06.009",
language = "English",
volume = "15",
pages = "1117--1124",
journal = "Journal of Sexual Medicine",
issn = "1743-6095",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Unrecognized Prediabetes Is Highly Prevalent in Men With Erectile Dysfunction–Results From a Cross-Sectional Study

AU - Boeri, Luca

AU - Capogrosso, Paolo

AU - Pederzoli, Filippo

AU - Ventimiglia, Eugenio

AU - Frego, Nicola

AU - Chierigo, Francesco

AU - Montanari, Emanuele

AU - Montorsi, Francesco

AU - Salonia, Andrea

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Introduction: The association between prediabetes (PreDM) and erectile dysfunction (ED) has been analyzed scantly. Aim: To assess the association between PreDM and erectile function (EF) in a cohort of white European men with ED. Methods: Demographic, clinical, and laboratory data from 372 consecutive men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). Patients were invited to complete the International Index of Erectile Function (IIEF)-EF domain questionnaire. The EF domain was categorized according to Cappelleri's criteria. Men were defined as having PreDM according to the criteria defined by the American Diabetes Association (2015). Descriptive statistics and logistic regression models tested the association between clinical variables and PreDM status and severe ED. Main Outcome Measures: We assessed the prevalence of PreDM in our cohort of men with ED and the potential association of PreDM and sexual health within the same cohort. Results: Of 372 men, +PreDM was found in 86 (23.1%) patients. Men with +PreDM had lower total testosterone (tT), higher triglycerides, and higher total cholesterol values (all P <.03) than those without PreDM. Likewise, +PreDM patients had a higher rate of CCI ≥1 (P =.03) and more frequently had severe ED (P =.013) compared with –PreDM. Age (OR 1.03; P =.01); lower tT (OR 0.81; P =.02); and severe ED (OR 3.37; P =.004) were associated with +PreDM status, after accounting for BMI, CCI, alcohol consumption, and cigarette smoking. Similarly, age (OR 1.02; P =.02) and +PreDM (OR 2.02; P =.02) were associated with severe ED, after accounting for other clinical variables. Clinical Implications: Identifying +PreDM status in ED men is clinically relevant in order to adopt preventive strategies to attempt and reduce risk of developing DM and subsequent cardiovascular diseases. Strengths & Limitations: To our knowledge, this is the first study evaluating the prevalence of unrecognized PreDM and the association of PreDM and ED severity in a real-life setting. Limitations are the retrospective nature of the cross-sectional study and the lack of haemodynamic parameters for every patient. Conclusions: 1 in 5 men seeking medical help for new-onset ED showed glucose values suggestive for unrecognized PreDM and +PreDM status was associated with worse hormonal and metabolic profiles, along with a higher risk of severe ED than −PreDM. Boeri L, Capogrosso P, Perderzoli F, et al. Unrecognized prediabetes is highly prevalent in men with erectile dysfunction–results from a cross-sectional study. J Sex Med 2018;15:1117–1124.

AB - Introduction: The association between prediabetes (PreDM) and erectile dysfunction (ED) has been analyzed scantly. Aim: To assess the association between PreDM and erectile function (EF) in a cohort of white European men with ED. Methods: Demographic, clinical, and laboratory data from 372 consecutive men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). Patients were invited to complete the International Index of Erectile Function (IIEF)-EF domain questionnaire. The EF domain was categorized according to Cappelleri's criteria. Men were defined as having PreDM according to the criteria defined by the American Diabetes Association (2015). Descriptive statistics and logistic regression models tested the association between clinical variables and PreDM status and severe ED. Main Outcome Measures: We assessed the prevalence of PreDM in our cohort of men with ED and the potential association of PreDM and sexual health within the same cohort. Results: Of 372 men, +PreDM was found in 86 (23.1%) patients. Men with +PreDM had lower total testosterone (tT), higher triglycerides, and higher total cholesterol values (all P <.03) than those without PreDM. Likewise, +PreDM patients had a higher rate of CCI ≥1 (P =.03) and more frequently had severe ED (P =.013) compared with –PreDM. Age (OR 1.03; P =.01); lower tT (OR 0.81; P =.02); and severe ED (OR 3.37; P =.004) were associated with +PreDM status, after accounting for BMI, CCI, alcohol consumption, and cigarette smoking. Similarly, age (OR 1.02; P =.02) and +PreDM (OR 2.02; P =.02) were associated with severe ED, after accounting for other clinical variables. Clinical Implications: Identifying +PreDM status in ED men is clinically relevant in order to adopt preventive strategies to attempt and reduce risk of developing DM and subsequent cardiovascular diseases. Strengths & Limitations: To our knowledge, this is the first study evaluating the prevalence of unrecognized PreDM and the association of PreDM and ED severity in a real-life setting. Limitations are the retrospective nature of the cross-sectional study and the lack of haemodynamic parameters for every patient. Conclusions: 1 in 5 men seeking medical help for new-onset ED showed glucose values suggestive for unrecognized PreDM and +PreDM status was associated with worse hormonal and metabolic profiles, along with a higher risk of severe ED than −PreDM. Boeri L, Capogrosso P, Perderzoli F, et al. Unrecognized prediabetes is highly prevalent in men with erectile dysfunction–results from a cross-sectional study. J Sex Med 2018;15:1117–1124.

KW - Diabetes

KW - Erectile Dysfunction

KW - Prediabetes

KW - Prevention

KW - Risk Factors

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=85050887296&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050887296&partnerID=8YFLogxK

U2 - 10.1016/j.jsxm.2018.06.009

DO - 10.1016/j.jsxm.2018.06.009

M3 - Article

AN - SCOPUS:85050887296

VL - 15

SP - 1117

EP - 1124

JO - Journal of Sexual Medicine

JF - Journal of Sexual Medicine

SN - 1743-6095

IS - 8

ER -