Unrelated cord blood compared with haploidentical grafts in patients with hematological malignancies

Jean El-Cheikh, Roberto Crocchiolo, Sabine Furst, Stefania Bramanti, Barbara Sarina, Angela Granata, Andrea Vai, Claude Lemarie, Catherine Faucher, Bilal Mohty, Samia Harbi, Reda Bouabdallah, Norbert Vey, Armando Santoro, Christian Chabannon, Luca Castagna, Didier Blaise

Research output: Contribution to journalArticle

Abstract

BACKGROUND Alternative donors, such as unrelated umbilical cord blood (UCB) and related haploidentical (haplo) donors, are more and more frequently searched for and used for patients who are candidates for allogeneic hematopoietic stem cell transplantation but are without a suitable related or unrelated donor. The aim of the current retrospective study was to compare the outcome of patients after haplo and UCB grafts prepared using a nonmyeloablative conditioning regimen. METHODS A total of 150 adult patients with high-risk hematologic diseases who underwent allogeneic hematopoietic stem cell transplantation from alternative donors at 2 centers (Paoli-Calmettes Institute [Marseille, France] and Humanitas Cancer Center [Milan, Italy]) were analyzed. Sixty-nine patients had haplo donors and 81 patients had UCB donors. RESULTS The cumulative incidence of nonrecurrence mortality at 1 year was 23% in the UCB group versus 17% in the haplo group (P-=-.39). The incidence of grade 2 to 4 acute graft-versus-host disease and extensive chronic graft-versus-host disease in the UCB group versus the haplo group was 52% versus 29% (P-=-.05) and 12% versus 6% (P

Original languageEnglish
Pages (from-to)1809-1816
Number of pages8
JournalCancer
Volume121
Issue number11
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • allogeneic hematopoietic stem cell transplantation
  • haploidentical donor
  • high-risk hematological diseases
  • nonmyeloablative conditioning regimen
  • unrelated umbilical cord blood

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Unrelated cord blood compared with haploidentical grafts in patients with hematological malignancies'. Together they form a unique fingerprint.

  • Cite this

    El-Cheikh, J., Crocchiolo, R., Furst, S., Bramanti, S., Sarina, B., Granata, A., Vai, A., Lemarie, C., Faucher, C., Mohty, B., Harbi, S., Bouabdallah, R., Vey, N., Santoro, A., Chabannon, C., Castagna, L., & Blaise, D. (2015). Unrelated cord blood compared with haploidentical grafts in patients with hematological malignancies. Cancer, 121(11), 1809-1816. https://doi.org/10.1002/cncr.29271