Unrelated cord blood transplantation: Outcomes after single-unit intrabone injection compared with double-unit intravenous injection in patients with hematological malignancies

Vanderson Rocha, Myriam Labopin, Annalisa Ruggeri, Marina Podestà, Andrea Gallamini, Francesca Bonifazi, Fermin M. Sanchez-Guijo, Montserrat Rovira, Gerard Socie, Ioannis Baltadakis, Mauricette Michallet, Eric Deconinck, Andrea Bacigalupo, Mohamad Mohty, Eliane Gluckman, Francesco Frassoni

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Unrelated cord blood transplantation (UCBT) is associated with delayed hematopoietic recovery. Intrabone injection of cord blood cells (IB-UCBT) and double-UCBT (dUCBT) are designed to circumvent this problem. METHODS: In a retrospective registry-based analysis, we compared outcomes of 87 IB-UCBT with 149 dUCBT recipients, after myeloablative conditioning regimen adjusting for the differences between the two groups. Median-infused total nucleated cells were 2.5×107/kg for IB-UCBT and 3.9×107/kg for dUCBT (P

Original languageEnglish
Pages (from-to)1284-1291
Number of pages8
JournalTransplantation
Volume95
Issue number10
DOIs
Publication statusPublished - May 27 2013

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Hematologic Neoplasms
Fetal Blood
Intravenous Injections
Transplantation
Injections
Registries
Blood Cells

Keywords

  • Double cord blood transplantation
  • Myeloablative conditioning regimen
  • Single-unit intrabone injection

ASJC Scopus subject areas

  • Transplantation

Cite this

Unrelated cord blood transplantation : Outcomes after single-unit intrabone injection compared with double-unit intravenous injection in patients with hematological malignancies. / Rocha, Vanderson; Labopin, Myriam; Ruggeri, Annalisa; Podestà, Marina; Gallamini, Andrea; Bonifazi, Francesca; Sanchez-Guijo, Fermin M.; Rovira, Montserrat; Socie, Gerard; Baltadakis, Ioannis; Michallet, Mauricette; Deconinck, Eric; Bacigalupo, Andrea; Mohty, Mohamad; Gluckman, Eliane; Frassoni, Francesco.

In: Transplantation, Vol. 95, No. 10, 27.05.2013, p. 1284-1291.

Research output: Contribution to journalArticle

Rocha, V, Labopin, M, Ruggeri, A, Podestà, M, Gallamini, A, Bonifazi, F, Sanchez-Guijo, FM, Rovira, M, Socie, G, Baltadakis, I, Michallet, M, Deconinck, E, Bacigalupo, A, Mohty, M, Gluckman, E & Frassoni, F 2013, 'Unrelated cord blood transplantation: Outcomes after single-unit intrabone injection compared with double-unit intravenous injection in patients with hematological malignancies', Transplantation, vol. 95, no. 10, pp. 1284-1291. https://doi.org/10.1097/TP.0b013e318288ca4d
Rocha, Vanderson ; Labopin, Myriam ; Ruggeri, Annalisa ; Podestà, Marina ; Gallamini, Andrea ; Bonifazi, Francesca ; Sanchez-Guijo, Fermin M. ; Rovira, Montserrat ; Socie, Gerard ; Baltadakis, Ioannis ; Michallet, Mauricette ; Deconinck, Eric ; Bacigalupo, Andrea ; Mohty, Mohamad ; Gluckman, Eliane ; Frassoni, Francesco. / Unrelated cord blood transplantation : Outcomes after single-unit intrabone injection compared with double-unit intravenous injection in patients with hematological malignancies. In: Transplantation. 2013 ; Vol. 95, No. 10. pp. 1284-1291.
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