Unrelated cord blood transplantation: Outcomes after single-unit intrabone injection compared with double-unit intravenous injection in patients with hematological malignancies

Vanderson Rocha, Myriam Labopin, Annalisa Ruggeri, Marina Podestà, Andrea Gallamini, Francesca Bonifazi, Fermin M. Sanchez-Guijo, Montserrat Rovira, Gerard Socie, Ioannis Baltadakis, Mauricette Michallet, Eric Deconinck, Andrea Bacigalupo, Mohamad Mohty, Eliane Gluckman, Francesco Frassoni

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Unrelated cord blood transplantation (UCBT) is associated with delayed hematopoietic recovery. Intrabone injection of cord blood cells (IB-UCBT) and double-UCBT (dUCBT) are designed to circumvent this problem. METHODS: In a retrospective registry-based analysis, we compared outcomes of 87 IB-UCBT with 149 dUCBT recipients, after myeloablative conditioning regimen adjusting for the differences between the two groups. Median-infused total nucleated cells were 2.5×107/kg for IB-UCBT and 3.9×107/kg for dUCBT (P

Original languageEnglish
Pages (from-to)1284-1291
Number of pages8
JournalTransplantation
Volume95
Issue number10
DOIs
Publication statusPublished - May 27 2013

Keywords

  • Double cord blood transplantation
  • Myeloablative conditioning regimen
  • Single-unit intrabone injection

ASJC Scopus subject areas

  • Transplantation

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