Unrelated-donor bone marrow transplantation for Philadelphia chromosome-positive chronic myelogenous leukemia in children: Experience of eight European countries

G. Dini, R. Rondelli, M. Miano, J. Vossen, E. Gluckman, C. Peters, P. Bordigoni, F. Locatelli, R. Miniero, P. Ljungman, U. Saarinen, T. Klingebiel, J. Ortega, E. Lanino

Research output: Contribution to journalArticle

Abstract

From September 1988 to December 1995 forty-four children (age 9/l at a median of 21 (range 14-88) days after transplantation. The remaining child failed to engraft. Two children developed secondary graft failure. A platelet count greater than 50 x 109/l sustained for at least seven consecutive days without transfusion support was reached at a median of 25 (range: 20-144) days by 24 out of 33 evaluable children and 9 children never recovered to above 50 x 109/l. Twenty-one out of 33 evaluable children developed grade I (n = 7), grade II (n = 8), grade III (n = 2) or grade IV (n = 4) acute GvHD (63%). Seven of the 30 evaluable children surviving more than 100 days developed chronic GvHD (20%) which was limited in 4 cases and extensive in 3. Relapse occurred in 3 of the 44 (7%) children at 2 to 24 months (median 14). Twenty-four month relapse rate was 14%. Seventeen out of 44 children (38%) died of transplant related mortality (TRM), 4 (9%) of secondary tumor, 4 (9%) of infections, 3 (7%) of organ failure, 1 (2%) of interstitial pneumonia, 5 (11%) of unknown causes. Actuarial TRM was 61% for children grafted before December 1991 and 33% for children grafted after January 1992 (p = .01). EFS was 49.7%; it was 65% for children receiving more than 3.5 x 109/Kg MNC.

Original languageEnglish
Pages (from-to)80-85
Number of pages6
JournalBone Marrow Transplantation
Volume18
Issue numberSUPPL. 2
Publication statusPublished - Nov 1996

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'Unrelated-donor bone marrow transplantation for Philadelphia chromosome-positive chronic myelogenous leukemia in children: Experience of eight European countries'. Together they form a unique fingerprint.

  • Cite this

    Dini, G., Rondelli, R., Miano, M., Vossen, J., Gluckman, E., Peters, C., Bordigoni, P., Locatelli, F., Miniero, R., Ljungman, P., Saarinen, U., Klingebiel, T., Ortega, J., & Lanino, E. (1996). Unrelated-donor bone marrow transplantation for Philadelphia chromosome-positive chronic myelogenous leukemia in children: Experience of eight European countries. Bone Marrow Transplantation, 18(SUPPL. 2), 80-85.