Unrelated HSCT in an adolescent affected by congenital erythropoietic porphyria

Maura Faraci, Giuseppe Morreale, Elio Boeri, Edoardo Lanino, Sandro Dallorso, Giorgio Dini, Francesca Scuderi, Amnon Cohen, Barbara Cappelli

Research output: Contribution to journalArticle

Abstract

CEP is a rare inborn error of porphyrin-heme synthesis. Clinical manifestations can range from mild to severe and include erythrodontia, reddish-colored urine, and hemolytic anemia that can be mild or severe and may result in splenomegaly. Completely avoiding exposure to the sun is crucial. Attempts to reduce erythropoiesis and to lower circulating porphyrin levels by means of erythrocyte transfusions have been successful in reducing the expression of the disease. However, the complications of a chronic transfusion regimen are potentially severe. Successful bone marrow transplantation has been reported in CEP. We report a case of successful bone marrow transplantation and prolonged follow-up in an adolescent CEP patient.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalPediatric Transplantation
Volume12
Issue number1
DOIs
Publication statusPublished - Feb 2008

Keywords

  • Age at transplant
  • Congenital erythropoietic porphyria
  • Follow-up
  • Hematopoietic stem cell transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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