Abstract
BACKGROUND: Percentage of heart rate reserve (%HRR) has been shown to be equivalent to percentage of VO2 reserve (%VO2R) in normal individuals, but it is not clear whether this is also true for chronic heart failure (CHF) patients. DESIGN: This study aimed to evaluate the reliability of the %VO2R versus %HRR relationship for aerobic effort relative intensity assessment in CHF patients. METHODS: We studied 388 patients with CHF, of whom 213 were on carvedilol (CHF on βb) and 175 were off the drug (CHF off βb), and 40 normal individuals (N). %VO2R and %HRR values were evaluated at matched steps during cardiopulmonary exercise testing. The %VO2R versus %HRR regression was determined for each group (CHF, CHF on βb, CHF off βb, N) as a whole and as the mean of individual regressions. RESULTS: %VO2R strongly correlated with %HRR in both N and CHF, at both group and mean individual regressions, with slope and y-intercept values significantly lower and higher, respectively, in CHF than N. The 95% prediction interval of %VO2R for a given %HRR value was 24% points in N but rose to 41 in CHF, and the mean regression line coincided with identity line in N but not in CHF. These results were independent of beta-blockade. CONCLUSIONS: In CHF patients the %VO2R versus %HRR relationship is unreliable for assessment of aerobic effort relative intensity, because of a large prediction interval of %VO2R and lack of coincidence with the identity line, independently of beta-blocking therapy. This implies that the %VO2R versus %HRR relationship should be determined directly in each patient.
| Original language | English |
|---|---|
| Pages (from-to) | 92-98 |
| Number of pages | 7 |
| Journal | European Journal of Cardiovascular Prevention and Rehabilitation |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 2007 |
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Keywords
- Beta-blockers
- Chronic heart failure
- Heart rate reserve
- Relative effort intensity
- V reserve
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Rehabilitation
- Public Health, Environmental and Occupational Health
Cite this
Unreliability of the %VO2 reserve versus %heart rate reserve relationship for aerobic effort relative intensity assessment in chronic heart failure patients on or off beta-blocking therapy. / Mezzani, Alessandro; Corrà, Ugo; Giordano, Andrea; Cafagna, Michele; Adriano, Edvige Palazzo; Giannuzzi, Pantaleo.
In: European Journal of Cardiovascular Prevention and Rehabilitation, Vol. 14, No. 1, 02.2007, p. 92-98.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Unreliability of the %VO2 reserve versus %heart rate reserve relationship for aerobic effort relative intensity assessment in chronic heart failure patients on or off beta-blocking therapy
AU - Mezzani, Alessandro
AU - Corrà, Ugo
AU - Giordano, Andrea
AU - Cafagna, Michele
AU - Adriano, Edvige Palazzo
AU - Giannuzzi, Pantaleo
PY - 2007/2
Y1 - 2007/2
N2 - BACKGROUND: Percentage of heart rate reserve (%HRR) has been shown to be equivalent to percentage of VO2 reserve (%VO2R) in normal individuals, but it is not clear whether this is also true for chronic heart failure (CHF) patients. DESIGN: This study aimed to evaluate the reliability of the %VO2R versus %HRR relationship for aerobic effort relative intensity assessment in CHF patients. METHODS: We studied 388 patients with CHF, of whom 213 were on carvedilol (CHF on βb) and 175 were off the drug (CHF off βb), and 40 normal individuals (N). %VO2R and %HRR values were evaluated at matched steps during cardiopulmonary exercise testing. The %VO2R versus %HRR regression was determined for each group (CHF, CHF on βb, CHF off βb, N) as a whole and as the mean of individual regressions. RESULTS: %VO2R strongly correlated with %HRR in both N and CHF, at both group and mean individual regressions, with slope and y-intercept values significantly lower and higher, respectively, in CHF than N. The 95% prediction interval of %VO2R for a given %HRR value was 24% points in N but rose to 41 in CHF, and the mean regression line coincided with identity line in N but not in CHF. These results were independent of beta-blockade. CONCLUSIONS: In CHF patients the %VO2R versus %HRR relationship is unreliable for assessment of aerobic effort relative intensity, because of a large prediction interval of %VO2R and lack of coincidence with the identity line, independently of beta-blocking therapy. This implies that the %VO2R versus %HRR relationship should be determined directly in each patient.
AB - BACKGROUND: Percentage of heart rate reserve (%HRR) has been shown to be equivalent to percentage of VO2 reserve (%VO2R) in normal individuals, but it is not clear whether this is also true for chronic heart failure (CHF) patients. DESIGN: This study aimed to evaluate the reliability of the %VO2R versus %HRR relationship for aerobic effort relative intensity assessment in CHF patients. METHODS: We studied 388 patients with CHF, of whom 213 were on carvedilol (CHF on βb) and 175 were off the drug (CHF off βb), and 40 normal individuals (N). %VO2R and %HRR values were evaluated at matched steps during cardiopulmonary exercise testing. The %VO2R versus %HRR regression was determined for each group (CHF, CHF on βb, CHF off βb, N) as a whole and as the mean of individual regressions. RESULTS: %VO2R strongly correlated with %HRR in both N and CHF, at both group and mean individual regressions, with slope and y-intercept values significantly lower and higher, respectively, in CHF than N. The 95% prediction interval of %VO2R for a given %HRR value was 24% points in N but rose to 41 in CHF, and the mean regression line coincided with identity line in N but not in CHF. These results were independent of beta-blockade. CONCLUSIONS: In CHF patients the %VO2R versus %HRR relationship is unreliable for assessment of aerobic effort relative intensity, because of a large prediction interval of %VO2R and lack of coincidence with the identity line, independently of beta-blocking therapy. This implies that the %VO2R versus %HRR relationship should be determined directly in each patient.
KW - Beta-blockers
KW - Chronic heart failure
KW - Heart rate reserve
KW - Relative effort intensity
KW - V reserve
UR - http://www.scopus.com/inward/record.url?scp=33847053922&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847053922&partnerID=8YFLogxK
U2 - 10.1097/HJR.0b013e328011649b
DO - 10.1097/HJR.0b013e328011649b
M3 - Article
VL - 14
SP - 92
EP - 98
JO - European Journal of Cardiovascular Prevention and Rehabilitation
JF - European Journal of Cardiovascular Prevention and Rehabilitation
SN - 1741-8267
IS - 1
ER -