Unresolved problems in optimal therapy of pubertal disorders in oncological and bone marrow transplanted patients

M. Bozzola, A. Albanese, G. E. Butler, V. Cherubini, A. Cicognani, M. Caruso-Nicoletti, E. Crowne, V. De Sanctis, E. Di Battista, A. C S Hokken-Koelega, F. Severi, B. Wonke, L. Cavallo

Research output: Contribution to journalArticlepeer-review


Specialised clinics for the long-term follow-up of survivors from childhood cancer have developed over recent years. The problems encountered among patients who received multiple chemotherapy and radiotherapy can be challenging and require high expertise and close collaboration among different professionals (e.g. oncologists, endocrinologists, radiotherapists, psychologists). Endocrine disorders are often seen, particularly among those who received cranial radiotherapy or gonadotoxic chemotherapy; puberty can be affected and the spectrum of disorders may range from precocious or accelerated puberty to delayed, arrested or even absent pubertal development. Growth impairment can be multifactorial and growth hormone deficiency is an important but probably not the only factor involved. Many questions remain about the optimal management of this group of young patients. In the consensus guidelines that follow the overview an attempt is made to help optimise patients' growth and puberty by suggesting practical clinical approaches to some of the most challenging issues.

Original languageEnglish
Pages (from-to)997-1002
Number of pages6
JournalJournal of Pediatric Endocrinology and Metabolism
Issue numberSUPPL. 2
Publication statusPublished - 2001


  • Bone-marrow transplanted patients
  • Consensus guidelines
  • Growth hormone treatment
  • Oncological patients
  • Puberty
  • Total body irradiation

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health


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