Unstable Maternal Environment Affects Stress Response in Adult Mice in a Genotype-Dependent Manner

Matteo Di Segni, Diego Andolina, Alessandra Luchetti, Lucy Babicola, Lina Ilaras D'Apolito, Tiziana Pascucci, David Conversi, Alessandra Accoto, Francesca R. D'Amato, Rossella Ventura

Research output: Contribution to journalArticle

Abstract

Early postnatal events exert powerful effects on development, inducing persistent functional alterations in different brain network, such as the catecholamine prefrontal-accumbal system, and increasing the risk of developing psychiatric disorders later in life. However, a vast body of literature shows that the interaction between genetic factors and early environmental conditions is crucial for expression of psychopathologies in adulthood. We evaluated the long-lasting effects of a repeated cross-fostering (RCF) procedure in 2 inbred strains of mice (C57BL/6J, DBA/2), known to show a different susceptibility to the development and expression of stress-induced psychopathologies. Coping behavior (forced swimming test) and preference for a natural reinforcing stimulus (saccharine preference test) were assessed in adult female mice of both genotypes. Moreover, c-Fos stress-induced activity was assessed in different brain regions involved in stress response. In addition, we evaluated the enduring effects of RCF on catecholamine prefrontal-accumbal response to acute stress (restraint) using, for the first time, a new "dual probes" in vivo microdialysis procedure in mouse. RCF experience affects behavioral and neurochemical responses to acute stress in adulthood in opposite direction in the 2 genotypes, leading DBA mice toward an "anhedonic-like" phenotype and C57 mice toward an increased sensitivity for a natural reinforcing stimulus.

Original languageEnglish
Pages (from-to)4370-4380
Number of pages11
JournalCerebral Cortex
Volume26
Issue number11
DOIs
Publication statusPublished - Oct 1 2016

Fingerprint

Foster Home Care
Genotype
Mothers
Psychopathology
Catecholamines
Inbred DBA Mouse
Inbred Strains Mice
Psychological Adaptation
Microdialysis
Brain
Psychiatry
Phenotype

Keywords

  • anhedonia
  • dopamine
  • early environment
  • inbred strains
  • mice, prefrontal-accumbal system
  • stress

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Unstable Maternal Environment Affects Stress Response in Adult Mice in a Genotype-Dependent Manner. / Di Segni, Matteo; Andolina, Diego; Luchetti, Alessandra; Babicola, Lucy; D'Apolito, Lina Ilaras; Pascucci, Tiziana; Conversi, David; Accoto, Alessandra; D'Amato, Francesca R.; Ventura, Rossella.

In: Cerebral Cortex, Vol. 26, No. 11, 01.10.2016, p. 4370-4380.

Research output: Contribution to journalArticle

Di Segni, M, Andolina, D, Luchetti, A, Babicola, L, D'Apolito, LI, Pascucci, T, Conversi, D, Accoto, A, D'Amato, FR & Ventura, R 2016, 'Unstable Maternal Environment Affects Stress Response in Adult Mice in a Genotype-Dependent Manner', Cerebral Cortex, vol. 26, no. 11, pp. 4370-4380. https://doi.org/10.1093/cercor/bhv204
Di Segni, Matteo ; Andolina, Diego ; Luchetti, Alessandra ; Babicola, Lucy ; D'Apolito, Lina Ilaras ; Pascucci, Tiziana ; Conversi, David ; Accoto, Alessandra ; D'Amato, Francesca R. ; Ventura, Rossella. / Unstable Maternal Environment Affects Stress Response in Adult Mice in a Genotype-Dependent Manner. In: Cerebral Cortex. 2016 ; Vol. 26, No. 11. pp. 4370-4380.
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