TY - JOUR
T1 - Unsuccessful cimetidine treatment of peptic ulcer
T2 - Analysis of the factors involved
AU - Granelli, P.
AU - Angelini, G. P.
AU - Celli, L.
PY - 1984
Y1 - 1984
N2 - Healing rates were examined retrospectively in 124 outpatients with peptic ulcer who had received cimetidine for at least four weeks. Treatment was unsuccessful in 73 patients. A statistical analysis of the factors involved in treatment failure revealed that in patients with duodenal ulcers 60.6% of the treatment successes versus 26.8% of the treatment failures were nonsmokers (P <0.001). There was a significantly higher (P <0.01) incidence of varioliform gastritis among treatment failures (19.2%) than treatment successes (3.9%). The following factors seemed to have no influence on rates of ulcer healing: age, sex, duration of ulcer disease, duration (beyond four weeks) of cimetidine therapy, family history of peptic ulcer, alcohol consumption, and coffee consumption. Although there was a higher gastric:duodenal ulcer ratio as well as higher consumption of anti-inflammatory drugs in treatment failures than in treatment successes, the difference was not statistically significant.
AB - Healing rates were examined retrospectively in 124 outpatients with peptic ulcer who had received cimetidine for at least four weeks. Treatment was unsuccessful in 73 patients. A statistical analysis of the factors involved in treatment failure revealed that in patients with duodenal ulcers 60.6% of the treatment successes versus 26.8% of the treatment failures were nonsmokers (P <0.001). There was a significantly higher (P <0.01) incidence of varioliform gastritis among treatment failures (19.2%) than treatment successes (3.9%). The following factors seemed to have no influence on rates of ulcer healing: age, sex, duration of ulcer disease, duration (beyond four weeks) of cimetidine therapy, family history of peptic ulcer, alcohol consumption, and coffee consumption. Although there was a higher gastric:duodenal ulcer ratio as well as higher consumption of anti-inflammatory drugs in treatment failures than in treatment successes, the difference was not statistically significant.
UR - http://www.scopus.com/inward/record.url?scp=0021141072&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021141072&partnerID=8YFLogxK
M3 - Article
C2 - 6722860
AN - SCOPUS:0021141072
VL - 6
SP - 294
EP - 301
JO - Clinical Therapeutics
JF - Clinical Therapeutics
SN - 0149-2918
IS - 3
ER -