Unsuspected leiomyosarcoma: Treatment with a gonadotropin-releasing hormone analogue

William R. Meyer, Allan R. Mayer, Michael P. Diamond, Maria L. Carcangiu, Peter E. Schwartz, Alan H. DeCherney

Research output: Contribution to journalArticlepeer-review


We present a case of a 46-year-old woman evaluated for abnormal uterine bleeding and an enlarged uterus, with normal endometrial sampling. Three months of leuprolide acetate injections resulted in a nonenlarging uterus and resolution of iron deficiency anemia and menorrhagia. Intraoperative examination suggested leiomyosarcoma, which was confirmed by postoperative permanent histologic sections. Residual uterine sarcomatous disease was confirmed on reexploration. Similar cases will continue to raise arguments against conservative hormonal intervention in the perimenopausal woman with an enlarged uterus. As the gynecologist gains familiarity with the use of gonadotropinreleasing hormone analogue therapy in the treatment of myomatous uteri, the criteria for hysterectomy will become less rigid and the potential for delay in the diagnosis and treatment of sarcomatous disease will become more common. Physicians must be cognizant of this potential complication of conservative therapy of leiomyomata uteri.

Original languageEnglish
Pages (from-to)529-532
Number of pages4
JournalObstetrics and Gynecology
Issue number3
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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