TY - JOUR
T1 - Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis
AU - Levantini, Elena
AU - Giorgetti, Alessandra
AU - Cerisoli, Francesco
AU - Traggiai, Elisabetta
AU - Guidi, Alessandra
AU - Martin, Richard
AU - Acampora, Dario
AU - Aplan, Peter D.
AU - Keller, Gordon
AU - Simeone, Antonio
AU - Iscove, Norman N.
AU - Hoang, Trang
AU - Magli, Maria Cristina
PY - 2003/9/2
Y1 - 2003/9/2
N2 - Otx1 belongs to the paired class of homeobox genes and plays a pivotal role in brain development. Here, we show that Otx1 is expressed in hematopoietic pluripotent and erythroid progenitor cells. Moreover, bone marrow cells from mice lacking Otx1 exhibit a cell-autonomous impairment of the erythroid compartment. In agreement with these results, molecular analysis revealed decreased levels of erythroid genes that include the SCL and GATA-1 transcription factors. Accordingly, a gain of function of SCL rescues the erythroid deficiency in Otx1-/- mice. Taken together, our findings indicate a function for Otx1 in the regulation of blood cell production.
AB - Otx1 belongs to the paired class of homeobox genes and plays a pivotal role in brain development. Here, we show that Otx1 is expressed in hematopoietic pluripotent and erythroid progenitor cells. Moreover, bone marrow cells from mice lacking Otx1 exhibit a cell-autonomous impairment of the erythroid compartment. In agreement with these results, molecular analysis revealed decreased levels of erythroid genes that include the SCL and GATA-1 transcription factors. Accordingly, a gain of function of SCL rescues the erythroid deficiency in Otx1-/- mice. Taken together, our findings indicate a function for Otx1 in the regulation of blood cell production.
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U2 - 10.1073/pnas.1734071100
DO - 10.1073/pnas.1734071100
M3 - Article
C2 - 12934017
AN - SCOPUS:0042838331
VL - 100
SP - 10299
EP - 10303
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 18
ER -