Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis

Elena Levantini, Alessandra Giorgetti, Francesco Cerisoli, Elisabetta Traggiai, Alessandra Guidi, Richard Martin, Dario Acampora, Peter D. Aplan, Gordon Keller, Antonio Simeone, Norman N. Iscove, Trang Hoang, Maria Cristina Magli

Research output: Contribution to journalArticlepeer-review

Abstract

Otx1 belongs to the paired class of homeobox genes and plays a pivotal role in brain development. Here, we show that Otx1 is expressed in hematopoietic pluripotent and erythroid progenitor cells. Moreover, bone marrow cells from mice lacking Otx1 exhibit a cell-autonomous impairment of the erythroid compartment. In agreement with these results, molecular analysis revealed decreased levels of erythroid genes that include the SCL and GATA-1 transcription factors. Accordingly, a gain of function of SCL rescues the erythroid deficiency in Otx1-/- mice. Taken together, our findings indicate a function for Otx1 in the regulation of blood cell production.

Original languageEnglish
Pages (from-to)10299-10303
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number18
DOIs
Publication statusPublished - Sep 2 2003

ASJC Scopus subject areas

  • Genetics
  • General

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