Unusual and Fatal Case of an Undiagnosed Intravascular Large B-cell Lymphoma: The Oncologist’s Great Imitator

Rosario Barranco, Fiorella Caputo, Davide Bedocchi, Francesca Maria Elena Frigiolini, Lara Castelletti, Giulio Fraternali Orcioni, Francesco Ventura

Research output: Contribution to journalArticle

Abstract

Intravascular lymphoma (IVL) is a rare subtype of extranodal lymphomas that is characterized by the selective growth of neoplastic cells within the lumen of small vessels. Authors document the case of an unexpected death caused by an undiagnosed intravascular large B-cell lymphoma with multi-organ involvement, which had initially manifested as an infection and then as an unclarified central nervous system pathology. Histological examination showed a diffuse intravascular large B-cell brain lymphoma with prominent cerebral involvement. The relevance of the case report reveals the importance of an autopsy of an extremely rare and threatening pathology that in most cases is diagnosed only postmortem. As a result, the role of the forensic pathologist becomes particularly important. When specifically performing an in-depth autopsy evaluation with a specific histologic analysis, it is possible to identify the intravascular lymphoma and declare a more accurate cause of death.

Original languageEnglish
Pages (from-to)314-317
Number of pages4
JournalJournal of Forensic Sciences
Volume65
Issue number1
DOIs
Publication statusPublished - Jan 1 2020

Keywords

  • autopsy
  • central nervous system
  • forensic pathology
  • forensic science
  • intravascular lymphoma
  • neurological pathology
  • postmortem diagnosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Genetics

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    Barranco, R., Caputo, F., Bedocchi, D., Frigiolini, F. M. E., Castelletti, L., Fraternali Orcioni, G., & Ventura, F. (2020). Unusual and Fatal Case of an Undiagnosed Intravascular Large B-cell Lymphoma: The Oncologist’s Great Imitator. Journal of Forensic Sciences, 65(1), 314-317. https://doi.org/10.1111/1556-4029.14141