Abstract
We report here an unusual case of association between thyrotropin (TSH)- secreting pituitary adenoma and papillary thyroid carcinoma in a young female patient. Serum TSH levels did not significantly change after both stimulatory (thyrotropin-releasing hormone [TRH], domperidone) and inhibitory (bromocriptine levotriiodothyronine, [LT3], levothyroxine [LT4], LT4 plus LT3) tests, while a 67% decrease of serum TSH levels was obtained after acute administration of a somatostatin analog (SMS 201-995, 100 μg sc). Serum α-subunit levels and the α-subunit/TSH molar ratio were clearly elevated. Magnetic resonance imaging (MRI) revealed the presence of a pituitary adenoma (1 cm in diameter). Pitfalls arising from the failure to inhibit TSH secretion in a patient thyroidectomized for papillary cancer are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 181-183 |
| Number of pages | 3 |
| Journal | Thyroid |
| Volume | 8 |
| Issue number | 2 |
| Publication status | Published - 1998 |
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ASJC Scopus subject areas
- Endocrinology
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Unusual association between a thyrotropin-secreting pituitary adenoma and a papillary thyroid carcinoma. / Gasparoni, Pietro; Rubello, Domenico; Persani, Luca; Beck-Peccoz, Paolo.
In: Thyroid, Vol. 8, No. 2, 1998, p. 181-183.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Unusual association between a thyrotropin-secreting pituitary adenoma and a papillary thyroid carcinoma
AU - Gasparoni, Pietro
AU - Rubello, Domenico
AU - Persani, Luca
AU - Beck-Peccoz, Paolo
PY - 1998
Y1 - 1998
N2 - We report here an unusual case of association between thyrotropin (TSH)- secreting pituitary adenoma and papillary thyroid carcinoma in a young female patient. Serum TSH levels did not significantly change after both stimulatory (thyrotropin-releasing hormone [TRH], domperidone) and inhibitory (bromocriptine levotriiodothyronine, [LT3], levothyroxine [LT4], LT4 plus LT3) tests, while a 67% decrease of serum TSH levels was obtained after acute administration of a somatostatin analog (SMS 201-995, 100 μg sc). Serum α-subunit levels and the α-subunit/TSH molar ratio were clearly elevated. Magnetic resonance imaging (MRI) revealed the presence of a pituitary adenoma (1 cm in diameter). Pitfalls arising from the failure to inhibit TSH secretion in a patient thyroidectomized for papillary cancer are discussed.
AB - We report here an unusual case of association between thyrotropin (TSH)- secreting pituitary adenoma and papillary thyroid carcinoma in a young female patient. Serum TSH levels did not significantly change after both stimulatory (thyrotropin-releasing hormone [TRH], domperidone) and inhibitory (bromocriptine levotriiodothyronine, [LT3], levothyroxine [LT4], LT4 plus LT3) tests, while a 67% decrease of serum TSH levels was obtained after acute administration of a somatostatin analog (SMS 201-995, 100 μg sc). Serum α-subunit levels and the α-subunit/TSH molar ratio were clearly elevated. Magnetic resonance imaging (MRI) revealed the presence of a pituitary adenoma (1 cm in diameter). Pitfalls arising from the failure to inhibit TSH secretion in a patient thyroidectomized for papillary cancer are discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0031940359&partnerID=8YFLogxK
M3 - Article
VL - 8
SP - 181
EP - 183
JO - Thyroid
JF - Thyroid
SN - 1050-7256
IS - 2
ER -