Unusual association between a thyrotropin-secreting pituitary adenoma and a papillary thyroid carcinoma

Pietro Gasparoni; Domenico Rubello; Luca Persani; Paolo Beck-Peccoz

Unusual association between a thyrotropin-secreting pituitary adenoma and a papillary thyroid carcinoma

Pietro Gasparoni, Domenico Rubello, Luca Persani, Paolo Beck-Peccoz

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Abstract

We report here an unusual case of association between thyrotropin (TSH)- secreting pituitary adenoma and papillary thyroid carcinoma in a young female patient. Serum TSH levels did not significantly change after both stimulatory (thyrotropin-releasing hormone [TRH], domperidone) and inhibitory (bromocriptine levotriiodothyronine, [LT₃], levothyroxine [LT₄], LT₄ plus LT₃) tests, while a 67% decrease of serum TSH levels was obtained after acute administration of a somatostatin analog (SMS 201-995, 100 μg sc). Serum α-subunit levels and the α-subunit/TSH molar ratio were clearly elevated. Magnetic resonance imaging (MRI) revealed the presence of a pituitary adenoma (1 cm in diameter). Pitfalls arising from the failure to inhibit TSH secretion in a patient thyroidectomized for papillary cancer are discussed.

Original language	English
Pages (from-to)	181-183
Number of pages	3
Journal	Thyroid
Volume	8
Issue number	2
Publication status	Published - 1998

ASJC Scopus subject areas

Endocrinology

Cite this

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abstract = "We report here an unusual case of association between thyrotropin (TSH)- secreting pituitary adenoma and papillary thyroid carcinoma in a young female patient. Serum TSH levels did not significantly change after both stimulatory (thyrotropin-releasing hormone [TRH], domperidone) and inhibitory (bromocriptine levotriiodothyronine, [LT3], levothyroxine [LT4], LT4 plus LT3) tests, while a 67% decrease of serum TSH levels was obtained after acute administration of a somatostatin analog (SMS 201-995, 100 μg sc). Serum α-subunit levels and the α-subunit/TSH molar ratio were clearly elevated. Magnetic resonance imaging (MRI) revealed the presence of a pituitary adenoma (1 cm in diameter). Pitfalls arising from the failure to inhibit TSH secretion in a patient thyroidectomized for papillary cancer are discussed.",

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AU - Gasparoni, Pietro

AU - Rubello, Domenico

AU - Persani, Luca

AU - Beck-Peccoz, Paolo

PY - 1998

Y1 - 1998

N2 - We report here an unusual case of association between thyrotropin (TSH)- secreting pituitary adenoma and papillary thyroid carcinoma in a young female patient. Serum TSH levels did not significantly change after both stimulatory (thyrotropin-releasing hormone [TRH], domperidone) and inhibitory (bromocriptine levotriiodothyronine, [LT3], levothyroxine [LT4], LT4 plus LT3) tests, while a 67% decrease of serum TSH levels was obtained after acute administration of a somatostatin analog (SMS 201-995, 100 μg sc). Serum α-subunit levels and the α-subunit/TSH molar ratio were clearly elevated. Magnetic resonance imaging (MRI) revealed the presence of a pituitary adenoma (1 cm in diameter). Pitfalls arising from the failure to inhibit TSH secretion in a patient thyroidectomized for papillary cancer are discussed.

AB - We report here an unusual case of association between thyrotropin (TSH)- secreting pituitary adenoma and papillary thyroid carcinoma in a young female patient. Serum TSH levels did not significantly change after both stimulatory (thyrotropin-releasing hormone [TRH], domperidone) and inhibitory (bromocriptine levotriiodothyronine, [LT3], levothyroxine [LT4], LT4 plus LT3) tests, while a 67% decrease of serum TSH levels was obtained after acute administration of a somatostatin analog (SMS 201-995, 100 μg sc). Serum α-subunit levels and the α-subunit/TSH molar ratio were clearly elevated. Magnetic resonance imaging (MRI) revealed the presence of a pituitary adenoma (1 cm in diameter). Pitfalls arising from the failure to inhibit TSH secretion in a patient thyroidectomized for papillary cancer are discussed.

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Unusual association between a thyrotropin-secreting pituitary adenoma and a papillary thyroid carcinoma

Abstract

ASJC Scopus subject areas

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