Unusual association between a thyrotropin-secreting pituitary adenoma and a papillary thyroid carcinoma

Pietro Gasparoni, Domenico Rubello, Luca Persani, Paolo Beck-Peccoz

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We report here an unusual case of association between thyrotropin (TSH)- secreting pituitary adenoma and papillary thyroid carcinoma in a young female patient. Serum TSH levels did not significantly change after both stimulatory (thyrotropin-releasing hormone [TRH], domperidone) and inhibitory (bromocriptine levotriiodothyronine, [LT3], levothyroxine [LT4], LT4 plus LT3) tests, while a 67% decrease of serum TSH levels was obtained after acute administration of a somatostatin analog (SMS 201-995, 100 μg sc). Serum α-subunit levels and the α-subunit/TSH molar ratio were clearly elevated. Magnetic resonance imaging (MRI) revealed the presence of a pituitary adenoma (1 cm in diameter). Pitfalls arising from the failure to inhibit TSH secretion in a patient thyroidectomized for papillary cancer are discussed.

Original languageEnglish
Pages (from-to)181-183
Number of pages3
JournalThyroid
Volume8
Issue number2
Publication statusPublished - 1998

Fingerprint

Pituitary Neoplasms
Thyrotropin
Serum
Domperidone
Octreotide
Thyrotropin-Releasing Hormone
Bromocriptine
Somatostatin
Thyroxine
Magnetic Resonance Imaging
Papillary Thyroid cancer
Neoplasms

ASJC Scopus subject areas

  • Endocrinology

Cite this

Unusual association between a thyrotropin-secreting pituitary adenoma and a papillary thyroid carcinoma. / Gasparoni, Pietro; Rubello, Domenico; Persani, Luca; Beck-Peccoz, Paolo.

In: Thyroid, Vol. 8, No. 2, 1998, p. 181-183.

Research output: Contribution to journalArticle

Gasparoni, Pietro ; Rubello, Domenico ; Persani, Luca ; Beck-Peccoz, Paolo. / Unusual association between a thyrotropin-secreting pituitary adenoma and a papillary thyroid carcinoma. In: Thyroid. 1998 ; Vol. 8, No. 2. pp. 181-183.
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