Unusual association of adrenal pheochromocytoma and para-aortic neurofibroma in pregnancy

A. Moretti, M. Minuto, P. Berti, G. P. Bernini, M. Mannelli, P. Miccoli

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The association of pheochromocytoma (PHEO) and pregnancy is uncommon and life threatening for both the fetus and the mother. Early diagnosis and treatment is essential to decrease maternal and fetal mortality and to differentiate the disease from the more common pre-eclampsia. While medical treatment should be started immediately after diagnosis, the timing of surgical treatment is still debated. We describe the case of a 27-yr-old woman in the 18th week of pregnancy who showed a biochemical pattern typical of PHEO and, by imaging studies, 2 tumors with the same characteristics: the first localized on the right adrenal gland, the second at the right renal hilum. The patient underwent surgery because of suspicion of malignant PHEO with local metastasis, while histology revealed a rare association of a solitary PHEO and para-aortic neurofibroma, both tumors embryologically deriving from a common cell precursor.

Original languageEnglish
Pages (from-to)738-741
Number of pages4
JournalJournal of Endocrinological Investigation
Issue number8
Publication statusPublished - Sep 2006


  • Neurofibroma
  • Pheochromocytoma
  • Pregnancy

ASJC Scopus subject areas

  • Endocrinology

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