Abstract
Sporadic olivopontocerebellar atrophy (OPCA) is a neurodeggenerative disorder that presents a wide clinical spectrum. Motor neuron disease (MND) is characterized by a selective degeneration of motor neurons. A 60-year-old man developed slurred speech and unsteadiness of gait. He had also noticed difficulty in holding his head upright and shoulder weakness. The disease had a rapid progression. At the age of 63 years, magnetic resonance imaging supported a diagnosis of OPCA, and a diagnosis of MND was suggested by clinical and electrophysiological findings. He also had upward gaze palsy. A muscular biopsy showed sporadic ragged red and Cox deficient fibers. The present case could define a unique disorder, as the occasional occurrence of two degenerative disorders appears unlikely.
Original language | English |
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Pages (from-to) | 243-245 |
Number of pages | 3 |
Journal | Neurological Sciences |
Volume | 23 |
Issue number | 5 |
DOIs | |
Publication status | Published - Dec 2002 |
Keywords
- Amyotrophic lateral sclerosis
- Mitochondria disorders
- Motor neuron disease
- Olivopontocerebellar atrophy
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology