Unusual clinical features and early brain MRI lesions in a family with cerebral autosomal dominant arteriopathy

Alessandro Malandrini, P. Carrera, G. Ciacci, S. Gonnelli, M. Villanova, S. Palmeri, L. Vismara, V. Brancolini, E. Signorini, M. Ferrari, G. C. Guazzi

Research output: Contribution to journalArticle

Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a recently described inherited disorder. The pathologic gene maps on chromosome 19. The clinical spectrum of the disease consists of recurrent strokes, migraine, transient ischemic attacks, mood changes, and dementia. We report a genetically assessed CADASIL family with atypical clinical presentations of epileptic seizures. In two asymptomatic family members there were early brain abnormalities on MRI. Our report expands the clinical spectrum of CADASIL and suggests that it is possibly an undiagnosed disorder.

Original languageEnglish
Pages (from-to)1200-1203
Number of pages4
JournalNeurology
Volume48
Issue number5
Publication statusPublished - May 1997

ASJC Scopus subject areas

  • Neuroscience(all)

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    Malandrini, A., Carrera, P., Ciacci, G., Gonnelli, S., Villanova, M., Palmeri, S., Vismara, L., Brancolini, V., Signorini, E., Ferrari, M., & Guazzi, G. C. (1997). Unusual clinical features and early brain MRI lesions in a family with cerebral autosomal dominant arteriopathy. Neurology, 48(5), 1200-1203.