Unusual clustering of alu repeats within the 5'-flanking region of the human lysozyme gene

Maria Letizia Riccio, Gian Maria Rossolini

Research output: Contribution to journalArticle

Abstract

We report the nucleotide sequence of the 2.2-kb 5'-flanking region of the human lysozyme gene. Four Alu repeats are located within this upstream region. Classification and dating of these four Alu elements, as well as of the four Alu elements present within the human lysozyme structural gene, were performed. Transposition of the eight Alu repeats found in the human lysozyme locus has apparently occurred at four different times during the primate genome evolution. Considering that Alu repeats are interspersed throughout human DNA with an average spacing of 4 kb, the presence of eight such repeats within the 8-kb lysozyme gene region and, in particular, of four of them in the 2.2-kb region upstream of the structural gene, appears quite unusual.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalMitochondrial DNA
Volume4
Issue number2
DOIs
Publication statusPublished - 1993

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Keywords

  • Alu repeated sequences
  • Human lysozyme gene
  • Paleogenetic markers
  • Upstream region

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biochemistry
  • Endocrinology

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