TY - JOUR
T1 - Unusual clustering of alu repeats within the 5'-flanking region of the human lysozyme gene
AU - Riccio, Maria Letizia
AU - Rossolini, Gian Maria
PY - 1993
Y1 - 1993
N2 - We report the nucleotide sequence of the 2.2-kb 5'-flanking region of the human lysozyme gene. Four Alu repeats are located within this upstream region. Classification and dating of these four Alu elements, as well as of the four Alu elements present within the human lysozyme structural gene, were performed. Transposition of the eight Alu repeats found in the human lysozyme locus has apparently occurred at four different times during the primate genome evolution. Considering that Alu repeats are interspersed throughout human DNA with an average spacing of 4 kb, the presence of eight such repeats within the 8-kb lysozyme gene region and, in particular, of four of them in the 2.2-kb region upstream of the structural gene, appears quite unusual.
AB - We report the nucleotide sequence of the 2.2-kb 5'-flanking region of the human lysozyme gene. Four Alu repeats are located within this upstream region. Classification and dating of these four Alu elements, as well as of the four Alu elements present within the human lysozyme structural gene, were performed. Transposition of the eight Alu repeats found in the human lysozyme locus has apparently occurred at four different times during the primate genome evolution. Considering that Alu repeats are interspersed throughout human DNA with an average spacing of 4 kb, the presence of eight such repeats within the 8-kb lysozyme gene region and, in particular, of four of them in the 2.2-kb region upstream of the structural gene, appears quite unusual.
KW - Alu repeated sequences
KW - Human lysozyme gene
KW - Paleogenetic markers
KW - Upstream region
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U2 - 10.3109/10425179309020152
DO - 10.3109/10425179309020152
M3 - Article
C2 - 8173077
AN - SCOPUS:0027146174
VL - 4
SP - 129
EP - 134
JO - DNA Sequence - Journal of DNA Sequencing and Mapping
JF - DNA Sequence - Journal of DNA Sequencing and Mapping
SN - 1940-1736
IS - 2
ER -