Unusual cycloartane glycosides from Astragalus eremophilus

Angela Perrone, Milena Masullo, Carla Bassarello, Elena Bloise, Arafa Hamed, Patrizia Nigro, Cosimo Pizza, Sonia Piacente

Research output: Contribution to journalArticlepeer-review

Abstract

Eleven new cycloartane-type glycosides, named eremophilosides A-K have been isolated from the aerial parts of Astragalus eremophilus. Their structures were elucidated by MS and NMR experiments and the relative configurational analysis of eremophilosides C and D was carried out on the basis of the recently reported J-based method. Additionally, the cytotoxic activity of these compounds in MCF7 and U937 cell lines was evaluated. All tested compounds, except eremophilosides B, C, and J were found to inhibit slightly the growth (controlling the cell cycle) and/or to induce death processes in U937 cell line, the most susceptible cell line. Eremophilosides A and K resulted the most effective to induce cell death, the first by necrosis while the latter by apoptosis.

Original languageEnglish
Pages (from-to)5061-5071
Number of pages11
JournalTetrahedron
Volume64
Issue number22
DOIs
Publication statusPublished - May 26 2008

Keywords

  • Astragalus eremophilus
  • Cycloartane glycosides
  • Cytotoxic activity
  • NMR

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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