TY - JOUR
T1 - Unusual cytogenetic findings in a synovial sarcoma arising in the paranasal sinuses
AU - Bettio, Daniela
AU - Rizzi, Nicoletta
AU - Colombo, Piergiuseppe
AU - Bianchi, Paolo
AU - Gaetani, Paolo
PY - 2004/11
Y1 - 2004/11
N2 - A fresh specimen from an intracranial tumor, which was histopatologically classified as a synovial sarcoma, was investigated cytogenetically. The direct method failed to give any information due to a lack of mitotic cells after treatment with 70% acetic acid, whereas 6-day cultures showed a 45,XY,del(6q),-10 karyotype. The histologic evaluation was consistent with a synovial sarcoma, which is well characterized from a cytogenetic perspective and involves a t(X;18)(p11;q11) in more than 95% of cases. Reverse-transcription polymerase chain reaction analysis did not show the presence of the SYT-SSX chimeric gene.
AB - A fresh specimen from an intracranial tumor, which was histopatologically classified as a synovial sarcoma, was investigated cytogenetically. The direct method failed to give any information due to a lack of mitotic cells after treatment with 70% acetic acid, whereas 6-day cultures showed a 45,XY,del(6q),-10 karyotype. The histologic evaluation was consistent with a synovial sarcoma, which is well characterized from a cytogenetic perspective and involves a t(X;18)(p11;q11) in more than 95% of cases. Reverse-transcription polymerase chain reaction analysis did not show the presence of the SYT-SSX chimeric gene.
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U2 - 10.1016/j.cancergencyto.2004.03.010
DO - 10.1016/j.cancergencyto.2004.03.010
M3 - Article
C2 - 15527907
AN - SCOPUS:7444268488
VL - 155
SP - 79
EP - 81
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -