Unusual cytogenetic findings in a synovial sarcoma arising in the paranasal sinuses

Daniela Bettio, Nicoletta Rizzi, Piergiuseppe Colombo, Paolo Bianchi, Paolo Gaetani

Research output: Contribution to journalArticlepeer-review

Abstract

A fresh specimen from an intracranial tumor, which was histopatologically classified as a synovial sarcoma, was investigated cytogenetically. The direct method failed to give any information due to a lack of mitotic cells after treatment with 70% acetic acid, whereas 6-day cultures showed a 45,XY,del(6q),-10 karyotype. The histologic evaluation was consistent with a synovial sarcoma, which is well characterized from a cytogenetic perspective and involves a t(X;18)(p11;q11) in more than 95% of cases. Reverse-transcription polymerase chain reaction analysis did not show the presence of the SYT-SSX chimeric gene.

Original languageEnglish
Pages (from-to)79-81
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume155
Issue number1
DOIs
Publication statusPublished - Nov 2004

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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