Unusual early recurrence of granular dystrophy after deep anterior lamellar keratoplasty: Case report

Paolo Rama, Karl Anders Knutsson, Carmen Rojo, Paola Carrera, Maurizio Ferrari

Research output: Contribution to journalArticlepeer-review

Abstract

We report an atypical case of granular corneal dystrophy recurrence after deep anterior lamellar keratoplasty. We describe clinical features, histopathological analysis of the lamellar graft specimen and DNA analysis results. The slit-lamp examination and histopathological findings from the graft specimen indicated the confinement of the typical deposits of granular corneal dystrophy deep in the graft interface area. This localization is atypical, since in most cases recurrences in grafts tend to be initially superficial and situated in the epithelial or subepithelial corneal layers. Molecular genetic analysis revealed an already described mutation and a new intronic variant. The unusual localization and timing of this recurrence of granular corneal dystrophy after deep anterior lamellar keratoplasty suggests that corneal stromal keratocytes may play a role in the formation of granular deposits.

Original languageEnglish
Pages (from-to)126-128
Number of pages3
JournalArquivos Brasileiros de Oftalmologia
Volume76
Issue number2
DOIs
Publication statusPublished - 2013

Keywords

  • Cornea/ pathology
  • Corneal dystrophies, hereditary
  • Corneal keratocytes
  • Corneal stroma
  • Corneal transplantation
  • Epithelium, corneal/cytology
  • Recurrence

ASJC Scopus subject areas

  • Ophthalmology

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