TY - JOUR
T1 - Unusual high dose of tacrolimus in liver transplant patient, a case report
AU - Provenzani, Alessio
AU - Notarbartolo, Monica
AU - Labbozzetta, Manuela
AU - Poma, Paola
AU - D'Antoni, Adele
AU - Polidori, Piera
AU - Vizzini, Giovanni
AU - D'Alessandro, Natale
PY - 2012/4
Y1 - 2012/4
N2 - Case We describe the case of a liver transplant patient who had great difficulty in reaching the desired trough blood levels despite the use of high dose tacrolimus. The patient was homozygous for the CYP3A5*3 allele. However, the respective donor carried the wild-type CYP3A5*1/*1 genotype. Regarding ABCB1 SNPs at exon 21 and 26, the patient showed the 2677GT and 3435CC genotypes. For the corresponding donor we observed the 2677GG and 3435CC wild-type genotypes. One, two and three weeks after transplantation the patient received daily 0.219, 0.287 and 0.273 mg/kg of tacrolimus, respectively. However, the corresponding tacrolimus trough blood levels were of 4.6, 5.6 and 6.1 ng/mL. The tacrolimus target level of 10.4 ng/mL was finally reached after 1 month of therapy. During the entire period of observation the kidney showed no sign of damage. No other signs of toxicity were reported except for the occurrence of an isolated systolic hypertension. Conclusions CYP3A5 genotyping may represent a useful tool to better evaluate the appropriate initial dose of tacrolimus for patients carrying a liver with the CYP3A5*1/*1 genotype.
AB - Case We describe the case of a liver transplant patient who had great difficulty in reaching the desired trough blood levels despite the use of high dose tacrolimus. The patient was homozygous for the CYP3A5*3 allele. However, the respective donor carried the wild-type CYP3A5*1/*1 genotype. Regarding ABCB1 SNPs at exon 21 and 26, the patient showed the 2677GT and 3435CC genotypes. For the corresponding donor we observed the 2677GG and 3435CC wild-type genotypes. One, two and three weeks after transplantation the patient received daily 0.219, 0.287 and 0.273 mg/kg of tacrolimus, respectively. However, the corresponding tacrolimus trough blood levels were of 4.6, 5.6 and 6.1 ng/mL. The tacrolimus target level of 10.4 ng/mL was finally reached after 1 month of therapy. During the entire period of observation the kidney showed no sign of damage. No other signs of toxicity were reported except for the occurrence of an isolated systolic hypertension. Conclusions CYP3A5 genotyping may represent a useful tool to better evaluate the appropriate initial dose of tacrolimus for patients carrying a liver with the CYP3A5*1/*1 genotype.
KW - ABCB1
KW - CYP3A5
KW - Liver transplant
KW - Pharmacogenomics
KW - Single nucleotide polymorphisms
KW - Tacrolimus
KW - Trough blood levels
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U2 - 10.1007/s11096-012-9622-6
DO - 10.1007/s11096-012-9622-6
M3 - Article
C2 - 22422348
AN - SCOPUS:84862844607
VL - 34
SP - 269
EP - 271
JO - International Journal of Clinical Pharmacy
JF - International Journal of Clinical Pharmacy
SN - 2210-7703
IS - 2
ER -