Unusual high dose of tacrolimus in liver transplant patient, a case report

Alessio Provenzani, Monica Notarbartolo, Manuela Labbozzetta, Paola Poma, Adele D'Antoni, Piera Polidori, Giovanni Vizzini, Natale D'Alessandro

Research output: Contribution to journalArticlepeer-review

Abstract

Case We describe the case of a liver transplant patient who had great difficulty in reaching the desired trough blood levels despite the use of high dose tacrolimus. The patient was homozygous for the CYP3A5*3 allele. However, the respective donor carried the wild-type CYP3A5*1/*1 genotype. Regarding ABCB1 SNPs at exon 21 and 26, the patient showed the 2677GT and 3435CC genotypes. For the corresponding donor we observed the 2677GG and 3435CC wild-type genotypes. One, two and three weeks after transplantation the patient received daily 0.219, 0.287 and 0.273 mg/kg of tacrolimus, respectively. However, the corresponding tacrolimus trough blood levels were of 4.6, 5.6 and 6.1 ng/mL. The tacrolimus target level of 10.4 ng/mL was finally reached after 1 month of therapy. During the entire period of observation the kidney showed no sign of damage. No other signs of toxicity were reported except for the occurrence of an isolated systolic hypertension. Conclusions CYP3A5 genotyping may represent a useful tool to better evaluate the appropriate initial dose of tacrolimus for patients carrying a liver with the CYP3A5*1/*1 genotype.

Original languageEnglish
Pages (from-to)269-271
Number of pages3
JournalInternational Journal of Clinical Pharmacy
Volume34
Issue number2
DOIs
Publication statusPublished - Apr 2012

Keywords

  • ABCB1
  • CYP3A5
  • Liver transplant
  • Pharmacogenomics
  • Single nucleotide polymorphisms
  • Tacrolimus
  • Trough blood levels

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmaceutical Science
  • Pharmacology
  • Toxicology
  • Pharmacy

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