Unusual onset of a case of chronic recurrent multifocal osteomyelitis

M. Barrani, F. Massei, M. Scaglione, A. Paolicchi, S. Vitali, E. M. Ciancia, S. Crovella, M. C. Caparello, R. Consolini

Research output: Contribution to journalArticlepeer-review


Background: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare condition that commonly affects the clavicle and pelvis. Case presentation: We report here a case a 12 years old girl with CRMO arising with recurrent episodes of left supraorbital headache, followed by the appearance of a periorbital dyschromia. Magnetic resonance imaging (MRI) of the skull and orbits revealed an important subacute inflammatory process. Few months after, the child presented a painful swelling of the left clavicle; the histological examination of the related biopsy allowed to establish the diagnosis of CRMO. Conclusion: CRMO presenting as acute headache involving neurocranium is rare; to our knowledge this is the first recognized case in the world literature. This pathological condition is frequently misdiagnosed as infection or neoplasm and needs a deep investigation for the differential diagnosis. The physical, laboratoristic and instrumental diagnostic investigations of the patient and the treatment employed are described in detail.

Original languageEnglish
Article number60
JournalPediatric Rheumatology
Issue number1
Publication statusPublished - Dec 12 2015


  • Acute painful headache
  • Chronic recurrent multifocal osteomyelitis
  • CRMO

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health


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