Unusual peptides containing the 2,6-diaminopimelic acid framework: Stereocontrolled synthesis, X-ray analysis, and computational modelling. Part 2

R. Galeazzi; M. Garavelli; A. Grandi; M. Monari; G. Porzi; S. Sandri

doi:10.1016/S0957-4166(03)00541-X

Unusual peptides containing the 2,6-diaminopimelic acid framework: Stereocontrolled synthesis, X-ray analysis, and computational modelling. Part 2

R. Galeazzi, M. Garavelli, A. Grandi, M. Monari, G. Porzi, S. Sandri

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article

Abstract

The stereocontrolled synthesis of peptides 6, 9 and 14, structural variants of 2,6-diaminopimelic acid, was carried out starting from the chiral synthon 1, easily obtained from L-valine. The configuration of the introduced stereogenic centres has been assigned on the basis of ¹H NMR spectroscopic data. X-Ray crystal structure and conformation analysis of 5 are also reported.

Original language	English
Pages (from-to)	2639-2649
Number of pages	11
Journal	Tetrahedron: Asymmetry
Volume	14
Issue number	17
DOIs	https://doi.org/10.1016/S0957-4166(03)00541-X
Publication status	Published - Sep 5 2003

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ASJC Scopus subject areas

Inorganic Chemistry
Organic Chemistry
Materials Chemistry
Drug Discovery

Cite this

Galeazzi, R., Garavelli, M., Grandi, A., Monari, M., Porzi, G., & Sandri, S. (2003). Unusual peptides containing the 2,6-diaminopimelic acid framework: Stereocontrolled synthesis, X-ray analysis, and computational modelling. Part 2. Tetrahedron: Asymmetry, 14(17), 2639-2649. https://doi.org/10.1016/S0957-4166(03)00541-X

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10.1016/S0957-4166(03)00541-X