Unusual split chimaerism after mismatched T-depleted BMT

A. Terenzi, F. Aversa, A. Mencarelli, P. Pelicci, A. Velardi, K. Perruccio, M. F. Martelli, T. Adelmo

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of haploidentical T-depleted BMT that engrafted durably after a highly immunosuppressive conditioning regimen. DNA polymorphism analysis showed that granulocytes and monocytes were donor type but T and B lymphocytes were host derived. Host tolerance to donor antigens was documented. The patient suffered from serious recurrent CMV infections until split chimaerism shifted to full donor type 2 years post-BMT. Seven years after BMT the patient remains in complete remission.

Original languageEnglish
Pages (from-to)465-467
Number of pages3
JournalBone Marrow Transplantation
Volume18
Issue number2
Publication statusPublished - Aug 1996

Keywords

  • CMV
  • Mismatched T-depleted BMT
  • Split chimaerism

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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