Unusual split chimaerism after mismatched T-depleted BMT

A. Terenzi; F. Aversa; A. Mencarelli; P. Pelicci; A. Velardi; K. Perruccio; M. F. Martelli; T. Adelmo

Unusual split chimaerism after mismatched T-depleted BMT

A. Terenzi, F. Aversa, A. Mencarelli, P. Pelicci, A. Velardi, K. Perruccio, M. F. Martelli, T. Adelmo

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of haploidentical T-depleted BMT that engrafted durably after a highly immunosuppressive conditioning regimen. DNA polymorphism analysis showed that granulocytes and monocytes were donor type but T and B lymphocytes were host derived. Host tolerance to donor antigens was documented. The patient suffered from serious recurrent CMV infections until split chimaerism shifted to full donor type 2 years post-BMT. Seven years after BMT the patient remains in complete remission.

Original language	English
Pages (from-to)	465-467
Number of pages	3
Journal	Bone Marrow Transplantation
Volume	18
Issue number	2
Publication status	Published - Aug 1996

Keywords

CMV
Mismatched T-depleted BMT
Split chimaerism

ASJC Scopus subject areas

Hematology
Transplantation

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abstract = "We report a case of haploidentical T-depleted BMT that engrafted durably after a highly immunosuppressive conditioning regimen. DNA polymorphism analysis showed that granulocytes and monocytes were donor type but T and B lymphocytes were host derived. Host tolerance to donor antigens was documented. The patient suffered from serious recurrent CMV infections until split chimaerism shifted to full donor type 2 years post-BMT. Seven years after BMT the patient remains in complete remission.",

keywords = "CMV, Mismatched T-depleted BMT, Split chimaerism",

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pages = "465--467",

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T1 - Unusual split chimaerism after mismatched T-depleted BMT

AU - Terenzi, A.

AU - Aversa, F.

AU - Mencarelli, A.

AU - Pelicci, P.

AU - Velardi, A.

AU - Perruccio, K.

AU - Martelli, M. F.

AU - Adelmo, T.

PY - 1996/8

Y1 - 1996/8

N2 - We report a case of haploidentical T-depleted BMT that engrafted durably after a highly immunosuppressive conditioning regimen. DNA polymorphism analysis showed that granulocytes and monocytes were donor type but T and B lymphocytes were host derived. Host tolerance to donor antigens was documented. The patient suffered from serious recurrent CMV infections until split chimaerism shifted to full donor type 2 years post-BMT. Seven years after BMT the patient remains in complete remission.

AB - We report a case of haploidentical T-depleted BMT that engrafted durably after a highly immunosuppressive conditioning regimen. DNA polymorphism analysis showed that granulocytes and monocytes were donor type but T and B lymphocytes were host derived. Host tolerance to donor antigens was documented. The patient suffered from serious recurrent CMV infections until split chimaerism shifted to full donor type 2 years post-BMT. Seven years after BMT the patient remains in complete remission.

KW - CMV

KW - Mismatched T-depleted BMT

KW - Split chimaerism

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