Unveiling the enigma of the CNS as a B-cell fostering environment

Antonio Uccelli, Francesca Aloisi, Vito Pistoia

Research output: Contribution to journalArticlepeer-review


This Opinion deals with the apparent paradox between the 'immune privileged' status of the central nervous system (CNS) and its propensity to act as a B-cell fostering environment in a variety of neurological disorders. Evidence will be reviewed that: (i) molecules regulating B-cell homing and survival are produced in the CNS, (ii) in different neuroinflammatory diseases, B cells can undergo a local recapitulation of the differentiation occurring in secondary lymphoid organs and (iii) ectopic lymphoid follicles develop in the meninges of multiple sclerosis (MS) patients.

Original languageEnglish
Pages (from-to)254-259
Number of pages6
JournalTrends in Immunology
Issue number5
Publication statusPublished - May 2005

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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