Unveiling the role of TNF-α in mesenchymal stromal cell-mediated immunosuppression

Vito Pistoia, Lizzia Raffaghello

Research output: Contribution to journalArticle

Abstract

Mesenchymal stromal cells (MSCs) are multipotent progenitors of mesodermal origin that not only differentiate into osteoblasts, chondrocytes, connective stromal cells, and adipocytes, but also exert immunoregulatory activities, usually induced by soluble molecules released during the cross-talk between MSCs and their target immune cell populations. In this issue of the European Journal of Immunology, Dorronsoro et al. [Eur. J. Immunol. 2014. 44: 480-488] demonstrate for the first time that TNF-α released by activated T cells confers immunosuppressive properties upon MSCs by binding to TNF-R1 and activating the NF-kB pathway. Such findings may improve our knowledge of the mechanisms underlying the reported efficacy of human MSCs administered locally or systemically to patients with autoimmune/inflammatory disorders, such as Crohn's disease and graft versus host disease, as discussed in this commentary.

Original languageEnglish
Pages (from-to)352-356
Number of pages5
JournalEuropean Journal of Immunology
Volume44
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Immunoregulation
  • Mesenchymal stromal cell
  • NF-kB
  • TNF-α

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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