Up-date on the antiphospholipid syndrome

Cristina Luzzana, Maria Gerosa, Piersandro Riboldi, Pier Luigi Meroni

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Antiphospholipid syndrome is defined by recurrent thrombotic events and fetal losses in the presence of anti-phospholipid antibodies detectable by beta 2 glycoprotein I-dependent anti-cardiolipin and/or lupus anticoagulant assays. Thrombosis can occur in any vascular district but deep veins and cerebral arteries represent the most frequent sites. Both early and late fetal losses have been reported in women affected by the syndrome as well as pre-eclampsia. Beta 2 glycoprotein I-dependent anti-cardiolipin and lupus anticoagulant are the formal laboratory diagnostic tools; new assays appear to improve the diagnostic power, but larger validation studies are needed before accepting them on a routine basis. In spite of the improvement in our knowledge on the pathogenic mechanisms of the syndrome, the standard therapy is still based on anti-platelet or anticoagulant drugs both for vascular and obstetrical problems.

Original languageEnglish
Pages (from-to)342-348
Number of pages7
JournalJournal of Nephrology
Volume15
Issue number4
Publication statusPublished - Jul 2002

Fingerprint

beta 2-Glycoprotein I
Lupus Coagulation Inhibitor
Cardiolipins
Antiphospholipid Syndrome
Blood Vessels
Cerebral Arteries
Validation Studies
Pre-Eclampsia
Anticoagulants
Anti-Idiotypic Antibodies
Veins
Phospholipids
Thrombosis
Blood Platelets
Therapeutics

Keywords

  • Anti-phospholipid antibodies
  • Fetal loss
  • Thrombosis

ASJC Scopus subject areas

  • Nephrology

Cite this

Luzzana, C., Gerosa, M., Riboldi, P., & Meroni, P. L. (2002). Up-date on the antiphospholipid syndrome. Journal of Nephrology, 15(4), 342-348.

Up-date on the antiphospholipid syndrome. / Luzzana, Cristina; Gerosa, Maria; Riboldi, Piersandro; Meroni, Pier Luigi.

In: Journal of Nephrology, Vol. 15, No. 4, 07.2002, p. 342-348.

Research output: Contribution to journalArticle

Luzzana, C, Gerosa, M, Riboldi, P & Meroni, PL 2002, 'Up-date on the antiphospholipid syndrome', Journal of Nephrology, vol. 15, no. 4, pp. 342-348.
Luzzana C, Gerosa M, Riboldi P, Meroni PL. Up-date on the antiphospholipid syndrome. Journal of Nephrology. 2002 Jul;15(4):342-348.
Luzzana, Cristina ; Gerosa, Maria ; Riboldi, Piersandro ; Meroni, Pier Luigi. / Up-date on the antiphospholipid syndrome. In: Journal of Nephrology. 2002 ; Vol. 15, No. 4. pp. 342-348.
@article{16e50d74b91a4201bf1f042570439a4d,
title = "Up-date on the antiphospholipid syndrome",
abstract = "Antiphospholipid syndrome is defined by recurrent thrombotic events and fetal losses in the presence of anti-phospholipid antibodies detectable by beta 2 glycoprotein I-dependent anti-cardiolipin and/or lupus anticoagulant assays. Thrombosis can occur in any vascular district but deep veins and cerebral arteries represent the most frequent sites. Both early and late fetal losses have been reported in women affected by the syndrome as well as pre-eclampsia. Beta 2 glycoprotein I-dependent anti-cardiolipin and lupus anticoagulant are the formal laboratory diagnostic tools; new assays appear to improve the diagnostic power, but larger validation studies are needed before accepting them on a routine basis. In spite of the improvement in our knowledge on the pathogenic mechanisms of the syndrome, the standard therapy is still based on anti-platelet or anticoagulant drugs both for vascular and obstetrical problems.",
keywords = "Anti-phospholipid antibodies, Fetal loss, Thrombosis",
author = "Cristina Luzzana and Maria Gerosa and Piersandro Riboldi and Meroni, {Pier Luigi}",
year = "2002",
month = "7",
language = "English",
volume = "15",
pages = "342--348",
journal = "Journal of Nephrology",
issn = "1121-8428",
publisher = "Springer International Publishing",
number = "4",

}

TY - JOUR

T1 - Up-date on the antiphospholipid syndrome

AU - Luzzana, Cristina

AU - Gerosa, Maria

AU - Riboldi, Piersandro

AU - Meroni, Pier Luigi

PY - 2002/7

Y1 - 2002/7

N2 - Antiphospholipid syndrome is defined by recurrent thrombotic events and fetal losses in the presence of anti-phospholipid antibodies detectable by beta 2 glycoprotein I-dependent anti-cardiolipin and/or lupus anticoagulant assays. Thrombosis can occur in any vascular district but deep veins and cerebral arteries represent the most frequent sites. Both early and late fetal losses have been reported in women affected by the syndrome as well as pre-eclampsia. Beta 2 glycoprotein I-dependent anti-cardiolipin and lupus anticoagulant are the formal laboratory diagnostic tools; new assays appear to improve the diagnostic power, but larger validation studies are needed before accepting them on a routine basis. In spite of the improvement in our knowledge on the pathogenic mechanisms of the syndrome, the standard therapy is still based on anti-platelet or anticoagulant drugs both for vascular and obstetrical problems.

AB - Antiphospholipid syndrome is defined by recurrent thrombotic events and fetal losses in the presence of anti-phospholipid antibodies detectable by beta 2 glycoprotein I-dependent anti-cardiolipin and/or lupus anticoagulant assays. Thrombosis can occur in any vascular district but deep veins and cerebral arteries represent the most frequent sites. Both early and late fetal losses have been reported in women affected by the syndrome as well as pre-eclampsia. Beta 2 glycoprotein I-dependent anti-cardiolipin and lupus anticoagulant are the formal laboratory diagnostic tools; new assays appear to improve the diagnostic power, but larger validation studies are needed before accepting them on a routine basis. In spite of the improvement in our knowledge on the pathogenic mechanisms of the syndrome, the standard therapy is still based on anti-platelet or anticoagulant drugs both for vascular and obstetrical problems.

KW - Anti-phospholipid antibodies

KW - Fetal loss

KW - Thrombosis

UR - http://www.scopus.com/inward/record.url?scp=0036659775&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036659775&partnerID=8YFLogxK

M3 - Article

C2 - 12243362

AN - SCOPUS:0036659775

VL - 15

SP - 342

EP - 348

JO - Journal of Nephrology

JF - Journal of Nephrology

SN - 1121-8428

IS - 4

ER -