Up-regulation of DMN connectivity in mild cognitive impairment via network-based cognitive training

Matteo De Marco, Francesca Meneghello, Cristina Pilosio, Jessica Rigon, Annalena Venneri

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND: Previous work designed a network-based protocol of cognitive training. This programme exploits a mechanism of induced task-oriented co-activation of multiple regions that are part of the default mode network (DMN), to induce functional rewiring and increased functional connectivity within this network.

OBJECTIVE: In this study, the programme was administered to patients with a diagnosis of mild cognitive impairment to test its effects in a clinical sample.

METHOD: Twenty-three patients with mild cognitive impairment (mean age: 73.74 years, standard deviation 5.13, female/male ratio 13/10) allocated to the experimental condition underwent one month of computerised training, while fourteen patients (mean age: 73.14 years, standard deviation 6.16, female/male ratio 7/7) assigned to the control condition underwent a regime of intense social engagement. Patients were in the prodromal stage of Alzheimer's disease (AD) as confirmed by clinical follow ups for at least two years. The DMN was computed at baseline and retest, together with other, control patterns of connectivity, grey matter maps, and neuropsychological profiles.

RESULTS: A condition-by-timepoint interaction indicating increased connectivity triggered by the programme was found in left parietal DMN regions. No decreases as well as no changes in the other networks or morphology were found. Although between-condition cognitive changes did not reach statistical significance, they correlated positively with changes in DMN connectivity in the left parietal region, supporting the hypothesis that parietal changes were beneficial.

CONCLUSION: This programme of cognitive training up-regulates a pattern of connectivity which is pathologically down-regulated in AD. We argue that, when cognitive interventions are conceptualised as tools to induce co-activation repeatedly, it can lead to clinically-relevant improvements in brain functioning, and can be of aid in support of pharmacological and other interventions in the earliest stages of AD.

Original languageEnglish
JournalCurrent Alzheimer Research
DOIs
Publication statusPublished - May 2018

Fingerprint

Up-Regulation
Alzheimer Disease
Prodromal Symptoms
Parietal Lobe
Pharmacology
Education
Cognitive Dysfunction
Brain

Cite this

Up-regulation of DMN connectivity in mild cognitive impairment via network-based cognitive training. / De Marco, Matteo; Meneghello, Francesca; Pilosio, Cristina; Rigon, Jessica; Venneri, Annalena.

In: Current Alzheimer Research, 05.2018.

Research output: Contribution to journalArticle

@article{4b6d9296599f4426b8c280b65474db9e,
title = "Up-regulation of DMN connectivity in mild cognitive impairment via network-based cognitive training",
abstract = "BACKGROUND: Previous work designed a network-based protocol of cognitive training. This programme exploits a mechanism of induced task-oriented co-activation of multiple regions that are part of the default mode network (DMN), to induce functional rewiring and increased functional connectivity within this network.OBJECTIVE: In this study, the programme was administered to patients with a diagnosis of mild cognitive impairment to test its effects in a clinical sample.METHOD: Twenty-three patients with mild cognitive impairment (mean age: 73.74 years, standard deviation 5.13, female/male ratio 13/10) allocated to the experimental condition underwent one month of computerised training, while fourteen patients (mean age: 73.14 years, standard deviation 6.16, female/male ratio 7/7) assigned to the control condition underwent a regime of intense social engagement. Patients were in the prodromal stage of Alzheimer's disease (AD) as confirmed by clinical follow ups for at least two years. The DMN was computed at baseline and retest, together with other, control patterns of connectivity, grey matter maps, and neuropsychological profiles.RESULTS: A condition-by-timepoint interaction indicating increased connectivity triggered by the programme was found in left parietal DMN regions. No decreases as well as no changes in the other networks or morphology were found. Although between-condition cognitive changes did not reach statistical significance, they correlated positively with changes in DMN connectivity in the left parietal region, supporting the hypothesis that parietal changes were beneficial.CONCLUSION: This programme of cognitive training up-regulates a pattern of connectivity which is pathologically down-regulated in AD. We argue that, when cognitive interventions are conceptualised as tools to induce co-activation repeatedly, it can lead to clinically-relevant improvements in brain functioning, and can be of aid in support of pharmacological and other interventions in the earliest stages of AD.",
author = "{De Marco}, Matteo and Francesca Meneghello and Cristina Pilosio and Jessica Rigon and Annalena Venneri",
note = "Copyright{\circledC} Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.",
year = "2018",
month = "5",
doi = "10.2174/1567205015666171212103323",
language = "English",
journal = "Current Alzheimer Research",
issn = "1567-2050",
publisher = "Bentham Science Publishers B.V.",

}

TY - JOUR

T1 - Up-regulation of DMN connectivity in mild cognitive impairment via network-based cognitive training

AU - De Marco, Matteo

AU - Meneghello, Francesca

AU - Pilosio, Cristina

AU - Rigon, Jessica

AU - Venneri, Annalena

N1 - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

PY - 2018/5

Y1 - 2018/5

N2 - BACKGROUND: Previous work designed a network-based protocol of cognitive training. This programme exploits a mechanism of induced task-oriented co-activation of multiple regions that are part of the default mode network (DMN), to induce functional rewiring and increased functional connectivity within this network.OBJECTIVE: In this study, the programme was administered to patients with a diagnosis of mild cognitive impairment to test its effects in a clinical sample.METHOD: Twenty-three patients with mild cognitive impairment (mean age: 73.74 years, standard deviation 5.13, female/male ratio 13/10) allocated to the experimental condition underwent one month of computerised training, while fourteen patients (mean age: 73.14 years, standard deviation 6.16, female/male ratio 7/7) assigned to the control condition underwent a regime of intense social engagement. Patients were in the prodromal stage of Alzheimer's disease (AD) as confirmed by clinical follow ups for at least two years. The DMN was computed at baseline and retest, together with other, control patterns of connectivity, grey matter maps, and neuropsychological profiles.RESULTS: A condition-by-timepoint interaction indicating increased connectivity triggered by the programme was found in left parietal DMN regions. No decreases as well as no changes in the other networks or morphology were found. Although between-condition cognitive changes did not reach statistical significance, they correlated positively with changes in DMN connectivity in the left parietal region, supporting the hypothesis that parietal changes were beneficial.CONCLUSION: This programme of cognitive training up-regulates a pattern of connectivity which is pathologically down-regulated in AD. We argue that, when cognitive interventions are conceptualised as tools to induce co-activation repeatedly, it can lead to clinically-relevant improvements in brain functioning, and can be of aid in support of pharmacological and other interventions in the earliest stages of AD.

AB - BACKGROUND: Previous work designed a network-based protocol of cognitive training. This programme exploits a mechanism of induced task-oriented co-activation of multiple regions that are part of the default mode network (DMN), to induce functional rewiring and increased functional connectivity within this network.OBJECTIVE: In this study, the programme was administered to patients with a diagnosis of mild cognitive impairment to test its effects in a clinical sample.METHOD: Twenty-three patients with mild cognitive impairment (mean age: 73.74 years, standard deviation 5.13, female/male ratio 13/10) allocated to the experimental condition underwent one month of computerised training, while fourteen patients (mean age: 73.14 years, standard deviation 6.16, female/male ratio 7/7) assigned to the control condition underwent a regime of intense social engagement. Patients were in the prodromal stage of Alzheimer's disease (AD) as confirmed by clinical follow ups for at least two years. The DMN was computed at baseline and retest, together with other, control patterns of connectivity, grey matter maps, and neuropsychological profiles.RESULTS: A condition-by-timepoint interaction indicating increased connectivity triggered by the programme was found in left parietal DMN regions. No decreases as well as no changes in the other networks or morphology were found. Although between-condition cognitive changes did not reach statistical significance, they correlated positively with changes in DMN connectivity in the left parietal region, supporting the hypothesis that parietal changes were beneficial.CONCLUSION: This programme of cognitive training up-regulates a pattern of connectivity which is pathologically down-regulated in AD. We argue that, when cognitive interventions are conceptualised as tools to induce co-activation repeatedly, it can lead to clinically-relevant improvements in brain functioning, and can be of aid in support of pharmacological and other interventions in the earliest stages of AD.

U2 - 10.2174/1567205015666171212103323

DO - 10.2174/1567205015666171212103323

M3 - Article

C2 - 29231140

JO - Current Alzheimer Research

JF - Current Alzheimer Research

SN - 1567-2050

ER -