Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma

Anna C. Berardi; Sonia Marsilio; Cristina Rofani; Ombretta Salvucci; Pierluigi Altavista; Francesco M. Perla; Francesca Diomedi-Camassei; Stefania Uccini; George Kokai; Lorena Landuzzi; Heather P. McDowell; Carlo Dominici

Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma

Anna C. Berardi, Sonia Marsilio, Cristina Rofani, Ombretta Salvucci, Pierluigi Altavista, Francesco M. Perla, Francesca Diomedi-Camassei, Stefania Uccini, George Kokai, Lorena Landuzzi, Heather P. McDowell, Carlo Dominici

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Increased expression of Eph receptors and their ephrin ligands has been implicated in promoting angiogenesis and tumour progression in several malignancies. Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated. Materials and Methods: Expression of mRNA for ephrin-B and EphB receptors in RMS cell lines and primary tumours was measured by real-time RT-PCR and compared with the expression in normal striated muscle. Results: A dysregulation of both ligands and receptors was found in all cell lines. In embryonal tumours, overexpression of ephrin-B1 correlated with overexpression of EphB1 (r=0.97, p

Original language	English
Pages (from-to)	763-769
Number of pages	7
Journal	Anticancer Research
Volume	28
Issue number	2 A
Publication status	Published - Mar 2008

Keywords

EphB receptors
Ephrin-B
Rhabdomyosarcoma

ASJC Scopus subject areas

Cancer Research
Oncology

Access to Document

Fingerprint Dive into the research topics of 'Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma'. Together they form a unique fingerprint.

Cite this

Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma. / Berardi, Anna C.; Marsilio, Sonia; Rofani, Cristina; Salvucci, Ombretta; Altavista, Pierluigi; Perla, Francesco M.; Diomedi-Camassei, Francesca; Uccini, Stefania; Kokai, George; Landuzzi, Lorena; McDowell, Heather P.; Dominici, Carlo.

In: Anticancer Research, Vol. 28, No. 2 A, 03.2008, p. 763-769.

Research output: Contribution to journal › Article › peer-review

Berardi, Anna C. ; Marsilio, Sonia ; Rofani, Cristina ; Salvucci, Ombretta ; Altavista, Pierluigi ; Perla, Francesco M. ; Diomedi-Camassei, Francesca ; Uccini, Stefania ; Kokai, George ; Landuzzi, Lorena ; McDowell, Heather P. ; Dominici, Carlo. / Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma. In: Anticancer Research. 2008 ; Vol. 28, No. 2 A. pp. 763-769.

@article{88ef444043f640c78b70d084e2481758,

title = "Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma",

abstract = "Background: Increased expression of Eph receptors and their ephrin ligands has been implicated in promoting angiogenesis and tumour progression in several malignancies. Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated. Materials and Methods: Expression of mRNA for ephrin-B and EphB receptors in RMS cell lines and primary tumours was measured by real-time RT-PCR and compared with the expression in normal striated muscle. Results: A dysregulation of both ligands and receptors was found in all cell lines. In embryonal tumours, overexpression of ephrin-B1 correlated with overexpression of EphB1 (r=0.97, p",

keywords = "EphB receptors, Ephrin-B, Rhabdomyosarcoma",

author = "Berardi, {Anna C.} and Sonia Marsilio and Cristina Rofani and Ombretta Salvucci and Pierluigi Altavista and Perla, {Francesco M.} and Francesca Diomedi-Camassei and Stefania Uccini and George Kokai and Lorena Landuzzi and McDowell, {Heather P.} and Carlo Dominici",

year = "2008",

month = mar,

language = "English",

volume = "28",

pages = "763--769",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "2 A",

}

TY - JOUR

T1 - Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma

AU - Berardi, Anna C.

AU - Marsilio, Sonia

AU - Rofani, Cristina

AU - Salvucci, Ombretta

AU - Altavista, Pierluigi

AU - Perla, Francesco M.

AU - Diomedi-Camassei, Francesca

AU - Uccini, Stefania

AU - Kokai, George

AU - Landuzzi, Lorena

AU - McDowell, Heather P.

AU - Dominici, Carlo

PY - 2008/3

Y1 - 2008/3

N2 - Background: Increased expression of Eph receptors and their ephrin ligands has been implicated in promoting angiogenesis and tumour progression in several malignancies. Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated. Materials and Methods: Expression of mRNA for ephrin-B and EphB receptors in RMS cell lines and primary tumours was measured by real-time RT-PCR and compared with the expression in normal striated muscle. Results: A dysregulation of both ligands and receptors was found in all cell lines. In embryonal tumours, overexpression of ephrin-B1 correlated with overexpression of EphB1 (r=0.97, p

AB - Background: Increased expression of Eph receptors and their ephrin ligands has been implicated in promoting angiogenesis and tumour progression in several malignancies. Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated. Materials and Methods: Expression of mRNA for ephrin-B and EphB receptors in RMS cell lines and primary tumours was measured by real-time RT-PCR and compared with the expression in normal striated muscle. Results: A dysregulation of both ligands and receptors was found in all cell lines. In embryonal tumours, overexpression of ephrin-B1 correlated with overexpression of EphB1 (r=0.97, p

KW - EphB receptors

KW - Ephrin-B

KW - Rhabdomyosarcoma

UR - http://www.scopus.com/inward/record.url?scp=42549091032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42549091032&partnerID=8YFLogxK

M3 - Article

C2 - 18507018

AN - SCOPUS:42549091032

VL - 28

SP - 763

EP - 769

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 2 A

ER -