Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma

Anna C. Berardi; Sonia Marsilio; Cristina Rofani; Ombretta Salvucci; Pierluigi Altavista; Francesco M. Perla; Francesca Diomedi-Camassei; Stefania Uccini; George Kokai; Lorena Landuzzi; Heather P. McDowell; Carlo Dominici

Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma

Anna C. Berardi, Sonia Marsilio, Cristina Rofani, Ombretta Salvucci, Pierluigi Altavista, Francesco M. Perla, Francesca Diomedi-Camassei, Stefania Uccini, George Kokai, Lorena Landuzzi, Heather P. McDowell, Carlo Dominici

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Increased expression of Eph receptors and their ephrin ligands has been implicated in promoting angiogenesis and tumour progression in several malignancies. Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated. Materials and Methods: Expression of mRNA for ephrin-B and EphB receptors in RMS cell lines and primary tumours was measured by real-time RT-PCR and compared with the expression in normal striated muscle. Results: A dysregulation of both ligands and receptors was found in all cell lines. In embryonal tumours, overexpression of ephrin-B1 correlated with overexpression of EphB1 (r=0.97, p

Original language	English
Pages (from-to)	763-769
Number of pages	7
Journal	Anticancer Research
Volume	28
Issue number	2 A
Publication status	Published - Mar 2008

Keywords

EphB receptors
Ephrin-B
Rhabdomyosarcoma

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma. / Berardi, Anna C.; Marsilio, Sonia; Rofani, Cristina; Salvucci, Ombretta; Altavista, Pierluigi; Perla, Francesco M.; Diomedi-Camassei, Francesca; Uccini, Stefania; Kokai, George; Landuzzi, Lorena; McDowell, Heather P.; Dominici, Carlo.

In: Anticancer Research, Vol. 28, No. 2 A, 03.2008, p. 763-769.

Research output: Contribution to journal › Article › peer-review

Berardi, Anna C. ; Marsilio, Sonia ; Rofani, Cristina ; Salvucci, Ombretta ; Altavista, Pierluigi ; Perla, Francesco M. ; Diomedi-Camassei, Francesca ; Uccini, Stefania ; Kokai, George ; Landuzzi, Lorena ; McDowell, Heather P. ; Dominici, Carlo. / Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma. In: Anticancer Research. 2008 ; Vol. 28, No. 2 A. pp. 763-769.

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abstract = "Background: Increased expression of Eph receptors and their ephrin ligands has been implicated in promoting angiogenesis and tumour progression in several malignancies. Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated. Materials and Methods: Expression of mRNA for ephrin-B and EphB receptors in RMS cell lines and primary tumours was measured by real-time RT-PCR and compared with the expression in normal striated muscle. Results: A dysregulation of both ligands and receptors was found in all cell lines. In embryonal tumours, overexpression of ephrin-B1 correlated with overexpression of EphB1 (r=0.97, p",

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AU - Berardi, Anna C.

AU - Marsilio, Sonia

AU - Rofani, Cristina

AU - Salvucci, Ombretta

AU - Altavista, Pierluigi

AU - Perla, Francesco M.

AU - Diomedi-Camassei, Francesca

AU - Uccini, Stefania

AU - Kokai, George

AU - Landuzzi, Lorena

AU - McDowell, Heather P.

AU - Dominici, Carlo

PY - 2008/3

Y1 - 2008/3

N2 - Background: Increased expression of Eph receptors and their ephrin ligands has been implicated in promoting angiogenesis and tumour progression in several malignancies. Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated. Materials and Methods: Expression of mRNA for ephrin-B and EphB receptors in RMS cell lines and primary tumours was measured by real-time RT-PCR and compared with the expression in normal striated muscle. Results: A dysregulation of both ligands and receptors was found in all cell lines. In embryonal tumours, overexpression of ephrin-B1 correlated with overexpression of EphB1 (r=0.97, p

AB - Background: Increased expression of Eph receptors and their ephrin ligands has been implicated in promoting angiogenesis and tumour progression in several malignancies. Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated. Materials and Methods: Expression of mRNA for ephrin-B and EphB receptors in RMS cell lines and primary tumours was measured by real-time RT-PCR and compared with the expression in normal striated muscle. Results: A dysregulation of both ligands and receptors was found in all cell lines. In embryonal tumours, overexpression of ephrin-B1 correlated with overexpression of EphB1 (r=0.97, p

KW - EphB receptors

KW - Ephrin-B

KW - Rhabdomyosarcoma

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Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma

Abstract

Keywords

ASJC Scopus subject areas

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