Abstract
Background: Increased expression of Eph receptors and their ephrin ligands has been implicated in promoting angiogenesis and tumour progression in several malignancies. Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated. Materials and Methods: Expression of mRNA for ephrin-B and EphB receptors in RMS cell lines and primary tumours was measured by real-time RT-PCR and compared with the expression in normal striated muscle. Results: A dysregulation of both ligands and receptors was found in all cell lines. In embryonal tumours, overexpression of ephrin-B1 correlated with overexpression of EphB1 (r=0.97, p
| Original language | English |
|---|---|
| Pages (from-to) | 763-769 |
| Number of pages | 7 |
| Journal | Anticancer Research |
| Volume | 28 |
| Issue number | 2 A |
| Publication status | Published - Mar 2008 |
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Keywords
- EphB receptors
- Ephrin-B
- Rhabdomyosarcoma
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Berardi, A. C., Marsilio, S., Rofani, C., Salvucci, O., Altavista, P., Perla, F. M., Diomedi-Camassei, F., Uccini, S., Kokai, G., Landuzzi, L., McDowell, H. P., & Dominici, C. (2008). Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma. Anticancer Research, 28(2 A), 763-769.