Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma

Anna C. Berardi, Sonia Marsilio, Cristina Rofani, Ombretta Salvucci, Pierluigi Altavista, Francesco M. Perla, Francesca Diomedi-Camassei, Stefania Uccini, George Kokai, Lorena Landuzzi, Heather P. McDowell, Carlo Dominici

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Abstract

Background: Increased expression of Eph receptors and their ephrin ligands has been implicated in promoting angiogenesis and tumour progression in several malignancies. Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated. Materials and Methods: Expression of mRNA for ephrin-B and EphB receptors in RMS cell lines and primary tumours was measured by real-time RT-PCR and compared with the expression in normal striated muscle. Results: A dysregulation of both ligands and receptors was found in all cell lines. In embryonal tumours, overexpression of ephrin-B1 correlated with overexpression of EphB1 (r=0.97, p

Original languageEnglish
Pages (from-to)763-769
Number of pages7
JournalAnticancer Research
Volume28
Issue number2 A
Publication statusPublished - Mar 2008

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Keywords

  • EphB receptors
  • Ephrin-B
  • Rhabdomyosarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Berardi, A. C., Marsilio, S., Rofani, C., Salvucci, O., Altavista, P., Perla, F. M., Diomedi-Camassei, F., Uccini, S., Kokai, G., Landuzzi, L., McDowell, H. P., & Dominici, C. (2008). Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma. Anticancer Research, 28(2 A), 763-769.