Abstract
Background: Increased expression of Eph receptors and their ephrin ligands has been implicated in promoting angiogenesis and tumour progression in several malignancies. Here the expression of mRNA for ephrin-B and EphB receptors in rhabdomyosarcoma (RMS) cell lines and primary tumours was investigated. Materials and Methods: Expression of mRNA for ephrin-B and EphB receptors in RMS cell lines and primary tumours was measured by real-time RT-PCR and compared with the expression in normal striated muscle. Results: A dysregulation of both ligands and receptors was found in all cell lines. In embryonal tumours, overexpression of ephrin-B1 correlated with overexpression of EphB1 (r=0.97, p
Original language | English |
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Pages (from-to) | 763-769 |
Number of pages | 7 |
Journal | Anticancer Research |
Volume | 28 |
Issue number | 2 A |
Publication status | Published - Mar 2008 |
Keywords
- EphB receptors
- Ephrin-B
- Rhabdomyosarcoma
ASJC Scopus subject areas
- Cancer Research
- Oncology