Update on beta-lactam allergy diagnosis

Pascal Demoly, Antonino Romano

Research output: Contribution to journalArticlepeer-review


Allergic reactions to penicillin and cephalosporin antibiotics are common. The mechanisms involved are heterogeneous and not yet completely understood. However, clinical and immunologic studies suggest that type I (IgE-mediated) and type IV (cell-mediated) pathogenic mechanisms are involved in most immediate and non-immediate reactions, respectively. The diagnostic procedure has recently been standardized under the aegis of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interest group on drug hypersensitivity. In this review, we describe the general guidelines for evaluating subjects in whom there is suspicion of allergic reactions to β-lactams.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalCurrent Allergy and Asthma Reports
Issue number1
Publication statusPublished - Jan 2005

ASJC Scopus subject areas

  • Medicine(all)


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