Update on extracorporeal photochemotherapy for graft-versus-host disease treatment

J. Kanold, C. Messina, F. Halle, F. Locatelli, E. Lanino, S. Cesaro, F. Deméocq

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Pediatric experience with extracorporeal photochemotherapy (ECP) for graft-versus-host disease (GvHD) has mainly been reported by Italian and French groups. Data concerning 41 children with acute GvHD and 63 children affected by chronic GvHD are available. In 73 and 63% of them, respectively, improvement was observed, with addition of ECP to their immunosuppressive regimen. Treatment with ECP was associated with minimal side effects, even in the smallest of patients. In all responded pediatric patients, both with acute and chronic GvHD, ECP allowed progressive reduction or discontinuation of the concomitant pharmacological immunosuppressive therapy without an increase in GvHD acitivity. These data show that ECP is a useful therapy for children affected by GvHD resistant to conventional treatment and can be safely used.

Original languageEnglish
JournalBone Marrow Transplantation
Volume35
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Mar 2005

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Photopheresis
Graft vs Host Disease
Immunosuppressive Agents
Therapeutics
Pediatrics
Pharmacology

Keywords

  • Children
  • Extracorporeal photochemotherapy
  • Graft-versus-host disease

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Update on extracorporeal photochemotherapy for graft-versus-host disease treatment. / Kanold, J.; Messina, C.; Halle, F.; Locatelli, F.; Lanino, E.; Cesaro, S.; Deméocq, F.

In: Bone Marrow Transplantation, Vol. 35, No. SUPPL. 1, 03.2005.

Research output: Contribution to journalArticle

Kanold, J. ; Messina, C. ; Halle, F. ; Locatelli, F. ; Lanino, E. ; Cesaro, S. ; Deméocq, F. / Update on extracorporeal photochemotherapy for graft-versus-host disease treatment. In: Bone Marrow Transplantation. 2005 ; Vol. 35, No. SUPPL. 1.
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