Update on mitochondria and muscle aging: All wrong roads lead to sarcopenia

Anna Picca, Riccardo Calvani, Maurizio Bossola, Elena Allocca, Amerigo Menghi, Vito Pesce, Angela Maria Serena Lezza, Roberto Bernabei, Francesco Landi, Emanuele Marzetti

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Sarcopenia is a well-known geriatric syndrome that has been endorsed over the years as a biomarker allowing for the discrimination, at a clinical level, of biological from chronological age. Multiple candidate mechanisms have been linked to muscle degeneration during sarcopenia. Among them, there is wide consensus on the central role played by the loss of mitochondrial integrity in myocytes, secondary to dysfunctional quality control mechanisms. Indeed, mitochondria establish direct or indirect contacts with other cellular components (e.g. endoplasmic reticulum, peroxisomes, lysosomes/vacuoles) as well as the extracellular environment through the release of several biomolecules. The functional implications of these interactions in the context of muscle physiology and sarcopenia are not yet fully appreciated and represent a promising area of investigation. Here, we present an overview of recent findings concerning the interrelation between mitochondrial quality control processes, inflammation and the metabolic regulation of muscle mass in the pathogenesis of sarcopenia highlighting those pathways that may be exploited for developing preventive and therapeutic interventions against muscle aging.

Original languageEnglish
Pages (from-to)421-436
Number of pages16
JournalBiological Chemistry
Volume399
Issue number5
DOIs
Publication statusPublished - Apr 25 2018

Fingerprint

Muscle Mitochondrion
Sarcopenia
Mitochondria
Muscle
Aging of materials
Muscles
Quality Control
Quality control
Geriatrics
Peroxisomes
Physiology
Biomolecules
Biomarkers
Vacuoles
Lysosomes
Endoplasmic Reticulum
Muscle Cells
Inflammation

Keywords

  • Inflammation
  • Mitochondrial biogenesis
  • Mitochondrial proteostasis
  • Mitochondrial quality control
  • Mitophagy
  • Muscle wasting

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Picca, A., Calvani, R., Bossola, M., Allocca, E., Menghi, A., Pesce, V., ... Marzetti, E. (2018). Update on mitochondria and muscle aging: All wrong roads lead to sarcopenia. Biological Chemistry, 399(5), 421-436. https://doi.org/10.1515/hsz-2017-0331

Update on mitochondria and muscle aging : All wrong roads lead to sarcopenia. / Picca, Anna; Calvani, Riccardo; Bossola, Maurizio; Allocca, Elena; Menghi, Amerigo; Pesce, Vito; Lezza, Angela Maria Serena; Bernabei, Roberto; Landi, Francesco; Marzetti, Emanuele.

In: Biological Chemistry, Vol. 399, No. 5, 25.04.2018, p. 421-436.

Research output: Contribution to journalReview article

Picca, A, Calvani, R, Bossola, M, Allocca, E, Menghi, A, Pesce, V, Lezza, AMS, Bernabei, R, Landi, F & Marzetti, E 2018, 'Update on mitochondria and muscle aging: All wrong roads lead to sarcopenia', Biological Chemistry, vol. 399, no. 5, pp. 421-436. https://doi.org/10.1515/hsz-2017-0331
Picca A, Calvani R, Bossola M, Allocca E, Menghi A, Pesce V et al. Update on mitochondria and muscle aging: All wrong roads lead to sarcopenia. Biological Chemistry. 2018 Apr 25;399(5):421-436. https://doi.org/10.1515/hsz-2017-0331
Picca, Anna ; Calvani, Riccardo ; Bossola, Maurizio ; Allocca, Elena ; Menghi, Amerigo ; Pesce, Vito ; Lezza, Angela Maria Serena ; Bernabei, Roberto ; Landi, Francesco ; Marzetti, Emanuele. / Update on mitochondria and muscle aging : All wrong roads lead to sarcopenia. In: Biological Chemistry. 2018 ; Vol. 399, No. 5. pp. 421-436.
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