Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature

Jennifer K. Bender, Vincent Cattoir, Kristin Hegstad, Ewa Sadowy, Teresa M. Coque, Henrik Westh, Anette M. Hammerum, Kirsten Schaffer, Karen Burns, Stephen Murchan, Carla Novais, Ana R. Freitas, Luísa Peixe, Maria Del Grosso, Annalisa Pantosti, Guido Werner

Research output: Contribution to journalArticle

Abstract

Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE infections are difficult to treat since common therapeutic options including ampicillin and glycopeptides often fail. In vitro, most VRE remain susceptible to last-resort antibiotics such as linezolid, tigecycline and daptomycin. However, neither tigecycline nor linezolid act in a bactericidal manner, and daptomycin has proven activity only at high dosages licensed for treating enterococcal endocarditis. Despite these pharmacological and therapeutic limitations, reports on resistance to these last-resort drugs in VRE, and enterococci in general, have increased in recent years. In this review, we briefly recapitulate the current knowledge on the mode of action as well as the known and novel mechanisms of resistance and describe surveillance data on resistance to linezolid, tigecycline and daptomycin in enterococci. In addition, we also suggest a common nomenclature for designating enterococci and VRE with resistances to these important last-resort antibiotics.

Original languageEnglish
Pages (from-to)25-39
Number of pages15
JournalDrug Resistance Updates
Volume40
DOIs
Publication statusPublished - Sep 1 2018

Keywords

  • Daptomycin
  • Linezolid
  • Tigecycline
  • vanA
  • vanB
  • VRE

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Cancer Research
  • Infectious Diseases
  • Pharmacology (medical)

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    Bender, J. K., Cattoir, V., Hegstad, K., Sadowy, E., Coque, T. M., Westh, H., Hammerum, A. M., Schaffer, K., Burns, K., Murchan, S., Novais, C., Freitas, A. R., Peixe, L., Del Grosso, M., Pantosti, A., & Werner, G. (2018). Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: Towards a common nomenclature. Drug Resistance Updates, 40, 25-39. https://doi.org/10.1016/j.drup.2018.10.002