Update on the antibiotic resistance crisis

Gian Maria Rossolini, Fabio Arena, Patrizia Pecile, Simona Pollini

Research output: Contribution to journalArticlepeer-review

Abstract

Antibiotics tend to lose their efficacy over time due to the emergence and dissemination of resistance among bacterial pathogens. Strains with resistance to multiple antibiotic classes have emerged among major Gram-positive and Gram-negative species including Staphylococcus aureus, Enterococcus spp., Pseudomonas aeruginosa, Acinetobacter spp. Enterobacteriaceae, and Neisseria gonorrhoeae. With some Gram-negatives, resistance may involve most or even all the available antimicrobial options, resulting in extremely drug-resistant or totally drug-resistant phenotypes. This so-called 'antibiotic resistance crisis' has been compounded by the lagging in antibiotic discovery and development programs occurred in recent years, and is jeopardizing the essential role played by antibiotics in current medical practices.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalCurrent Opinion in Pharmacology
Volume18
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Medicine(all)

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