Abstract
Antibiotics tend to lose their efficacy over time due to the emergence and dissemination of resistance among bacterial pathogens. Strains with resistance to multiple antibiotic classes have emerged among major Gram-positive and Gram-negative species including Staphylococcus aureus, Enterococcus spp., Pseudomonas aeruginosa, Acinetobacter spp. Enterobacteriaceae, and Neisseria gonorrhoeae. With some Gram-negatives, resistance may involve most or even all the available antimicrobial options, resulting in extremely drug-resistant or totally drug-resistant phenotypes. This so-called 'antibiotic resistance crisis' has been compounded by the lagging in antibiotic discovery and development programs occurred in recent years, and is jeopardizing the essential role played by antibiotics in current medical practices.
| Original language | English |
|---|---|
| Pages (from-to) | 56-60 |
| Number of pages | 5 |
| Journal | Current Opinion in Pharmacology |
| Volume | 18 |
| DOIs | |
| Publication status | Published - 2014 |
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ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
- Medicine(all)
Cite this
Update on the antibiotic resistance crisis. / Rossolini, Gian Maria; Arena, Fabio; Pecile, Patrizia; Pollini, Simona.
In: Current Opinion in Pharmacology, Vol. 18, 2014, p. 56-60.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Update on the antibiotic resistance crisis
AU - Rossolini, Gian Maria
AU - Arena, Fabio
AU - Pecile, Patrizia
AU - Pollini, Simona
PY - 2014
Y1 - 2014
N2 - Antibiotics tend to lose their efficacy over time due to the emergence and dissemination of resistance among bacterial pathogens. Strains with resistance to multiple antibiotic classes have emerged among major Gram-positive and Gram-negative species including Staphylococcus aureus, Enterococcus spp., Pseudomonas aeruginosa, Acinetobacter spp. Enterobacteriaceae, and Neisseria gonorrhoeae. With some Gram-negatives, resistance may involve most or even all the available antimicrobial options, resulting in extremely drug-resistant or totally drug-resistant phenotypes. This so-called 'antibiotic resistance crisis' has been compounded by the lagging in antibiotic discovery and development programs occurred in recent years, and is jeopardizing the essential role played by antibiotics in current medical practices.
AB - Antibiotics tend to lose their efficacy over time due to the emergence and dissemination of resistance among bacterial pathogens. Strains with resistance to multiple antibiotic classes have emerged among major Gram-positive and Gram-negative species including Staphylococcus aureus, Enterococcus spp., Pseudomonas aeruginosa, Acinetobacter spp. Enterobacteriaceae, and Neisseria gonorrhoeae. With some Gram-negatives, resistance may involve most or even all the available antimicrobial options, resulting in extremely drug-resistant or totally drug-resistant phenotypes. This so-called 'antibiotic resistance crisis' has been compounded by the lagging in antibiotic discovery and development programs occurred in recent years, and is jeopardizing the essential role played by antibiotics in current medical practices.
UR - http://www.scopus.com/inward/record.url?scp=84907581578&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907581578&partnerID=8YFLogxK
U2 - 10.1016/j.coph.2014.09.006
DO - 10.1016/j.coph.2014.09.006
M3 - Article
C2 - 25254623
AN - SCOPUS:84907581578
VL - 18
SP - 56
EP - 60
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
SN - 1471-4892
ER -