Update on the management of pediatric acute osteomyelitis and septic arthritis

Luca Castellazzi, Marco Mantero, Susanna Esposito

Research output: Contribution to journalReview articlepeer-review


Acute osteomyelitis and septic arthritis are two infections whose frequencies are increasing in pediatric patients. Acute osteomyelitis and septic arthritis need to be carefully assessed, diagnosed, and treated to avoid devastating sequelae. Traditionally, the treatment of acute osteoarticular infection in pediatrics was based on prolonged intravenous anti-infective therapy. However, results from clinical trials have suggested that in uncomplicated cases, a short course of a few days of parenteral antibiotics followed by oral therapy is safe and effective. The aim of this review is to provide clinicians an update on recent controversies and advances regarding the management of acute osteomyelitis and septic arthritis in children. In recent years, the emergence of bacterial species resistant to commonly used antibiotics that are particularly aggressive highlights the necessity for further research to optimize treatment approaches and to develop new molecules able to fight the war against acute osteoarticular infection in pediatric patients.

Original languageEnglish
Article number855
JournalInternational Journal of Molecular Sciences
Issue number6
Publication statusPublished - Jun 1 2016


  • Anti-infective therapy
  • Antibiotics
  • Osteoarticular infection
  • Osteomyelitis
  • Septic arthritis

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications


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