Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer

Maria Vittoria Dieci, Nina Radosevic-Robin, Susan Fineberg, Gert van den Eynden, Nils Ternes, Frederique Penault-Llorca, Giancarlo Pruneri, Timothy M D'Alfonso, Sandra Demaria, Carlos Castaneda, Joselyn Sanchez, Sunil Badve, Stefan Michiels, Veerle Bossuyt, Federico Rojo, Baljit Singh, Torsten Nielsen, Giuseppe Viale, Seong-Rim Kim, Stephen HewittStephan Wienert, Sybille Loibl, David Rimm, Fraser Symmans, Carsten Denkert, Sylvia Adams, Sherene Loi, Roberto Salgado, International Immuno-Oncology Biomarker Working Group on Breast Cancer

Research output: Contribution to journalReview article

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Abstract

Morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer is gaining momentum as evidence strengthens the clinical relevance of this immunological biomarker. TILs in the post-neoadjuvant residual disease setting are acquiring increasing importance as a stratifying marker in clinical trials, considering the raising interest on immunotherapeutic strategies after neoadjuvant chemotherapy. TILs in ductal carcinoma in situ, with or without invasive carcinoma, represent an emerging area of clinical breast cancer research. The aim of this report is to update pathologists, clinicians and researchers on TIL assessment in both the post-neoadjuvant residual disease and the ductal carcinoma in situ settings. The International Immuno-Oncology Working Group proposes a method for assessing TILs in these settings, based on the previously published International Guidelines on TIL Assessment in Breast Cancer. In this regard, these recommendations represent a consensus guidance for pathologists, aimed to achieve the highest possible consistency among future studies.

Original languageEnglish
Pages (from-to)16-25
JournalSeminars in Cancer Biology
DOIs
Publication statusPublished - Oct 2018

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Tumor-Infiltrating Lymphocytes
Neoadjuvant Therapy
Carcinoma in Situ
Biomarkers
Breast Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Research Personnel
Clinical Trials
Guidelines
Carcinoma
Drug Therapy
Research

Keywords

  • Journal Article
  • Review

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Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ : A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. / Dieci, Maria Vittoria; Radosevic-Robin, Nina; Fineberg, Susan; van den Eynden, Gert; Ternes, Nils; Penault-Llorca, Frederique; Pruneri, Giancarlo; D'Alfonso, Timothy M; Demaria, Sandra; Castaneda, Carlos; Sanchez, Joselyn; Badve, Sunil; Michiels, Stefan; Bossuyt, Veerle; Rojo, Federico; Singh, Baljit; Nielsen, Torsten; Viale, Giuseppe; Kim, Seong-Rim; Hewitt, Stephen; Wienert, Stephan; Loibl, Sybille; Rimm, David; Symmans, Fraser; Denkert, Carsten; Adams, Sylvia; Loi, Sherene; Salgado, Roberto; International Immuno-Oncology Biomarker Working Group on Breast Cancer.

In: Seminars in Cancer Biology, 10.2018, p. 16-25.

Research output: Contribution to journalReview article

Dieci, MV, Radosevic-Robin, N, Fineberg, S, van den Eynden, G, Ternes, N, Penault-Llorca, F, Pruneri, G, D'Alfonso, TM, Demaria, S, Castaneda, C, Sanchez, J, Badve, S, Michiels, S, Bossuyt, V, Rojo, F, Singh, B, Nielsen, T, Viale, G, Kim, S-R, Hewitt, S, Wienert, S, Loibl, S, Rimm, D, Symmans, F, Denkert, C, Adams, S, Loi, S, Salgado, R & International Immuno-Oncology Biomarker Working Group on Breast Cancer 2018, 'Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer', Seminars in Cancer Biology, pp. 16-25. https://doi.org/10.1016/j.semcancer.2017.10.003
Dieci, Maria Vittoria ; Radosevic-Robin, Nina ; Fineberg, Susan ; van den Eynden, Gert ; Ternes, Nils ; Penault-Llorca, Frederique ; Pruneri, Giancarlo ; D'Alfonso, Timothy M ; Demaria, Sandra ; Castaneda, Carlos ; Sanchez, Joselyn ; Badve, Sunil ; Michiels, Stefan ; Bossuyt, Veerle ; Rojo, Federico ; Singh, Baljit ; Nielsen, Torsten ; Viale, Giuseppe ; Kim, Seong-Rim ; Hewitt, Stephen ; Wienert, Stephan ; Loibl, Sybille ; Rimm, David ; Symmans, Fraser ; Denkert, Carsten ; Adams, Sylvia ; Loi, Sherene ; Salgado, Roberto ; International Immuno-Oncology Biomarker Working Group on Breast Cancer. / Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ : A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. In: Seminars in Cancer Biology. 2018 ; pp. 16-25.
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abstract = "Morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer is gaining momentum as evidence strengthens the clinical relevance of this immunological biomarker. TILs in the post-neoadjuvant residual disease setting are acquiring increasing importance as a stratifying marker in clinical trials, considering the raising interest on immunotherapeutic strategies after neoadjuvant chemotherapy. TILs in ductal carcinoma in situ, with or without invasive carcinoma, represent an emerging area of clinical breast cancer research. The aim of this report is to update pathologists, clinicians and researchers on TIL assessment in both the post-neoadjuvant residual disease and the ductal carcinoma in situ settings. The International Immuno-Oncology Working Group proposes a method for assessing TILs in these settings, based on the previously published International Guidelines on TIL Assessment in Breast Cancer. In this regard, these recommendations represent a consensus guidance for pathologists, aimed to achieve the highest possible consistency among future studies.",
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T2 - A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer

AU - Dieci, Maria Vittoria

AU - Radosevic-Robin, Nina

AU - Fineberg, Susan

AU - van den Eynden, Gert

AU - Ternes, Nils

AU - Penault-Llorca, Frederique

AU - Pruneri, Giancarlo

AU - D'Alfonso, Timothy M

AU - Demaria, Sandra

AU - Castaneda, Carlos

AU - Sanchez, Joselyn

AU - Badve, Sunil

AU - Michiels, Stefan

AU - Bossuyt, Veerle

AU - Rojo, Federico

AU - Singh, Baljit

AU - Nielsen, Torsten

AU - Viale, Giuseppe

AU - Kim, Seong-Rim

AU - Hewitt, Stephen

AU - Wienert, Stephan

AU - Loibl, Sybille

AU - Rimm, David

AU - Symmans, Fraser

AU - Denkert, Carsten

AU - Adams, Sylvia

AU - Loi, Sherene

AU - Salgado, Roberto

AU - International Immuno-Oncology Biomarker Working Group on Breast Cancer

N1 - Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Y1 - 2018/10

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AB - Morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer is gaining momentum as evidence strengthens the clinical relevance of this immunological biomarker. TILs in the post-neoadjuvant residual disease setting are acquiring increasing importance as a stratifying marker in clinical trials, considering the raising interest on immunotherapeutic strategies after neoadjuvant chemotherapy. TILs in ductal carcinoma in situ, with or without invasive carcinoma, represent an emerging area of clinical breast cancer research. The aim of this report is to update pathologists, clinicians and researchers on TIL assessment in both the post-neoadjuvant residual disease and the ductal carcinoma in situ settings. The International Immuno-Oncology Working Group proposes a method for assessing TILs in these settings, based on the previously published International Guidelines on TIL Assessment in Breast Cancer. In this regard, these recommendations represent a consensus guidance for pathologists, aimed to achieve the highest possible consistency among future studies.

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