Update on vaccines for melanoma patients

Vincenzo Russo, Cristina Maccalli, Lorenzo Pilla, Santo Raffaele Mercuri, Elena Orsenigo, Sylvain Mukenge, Marco Bregni, Giorgio Parmiani

Research output: Contribution to journalArticlepeer-review

Abstract

Vaccination against melanoma has a long history but only recently has this therapeutic approach found a reliable scientific rationale. This review summarizes and updates the knowledge on the role of the main players in the vaccination strategy against metastatic melanoma, that is, the melanoma-associated antigens recognized by T and natural killer T lymphocytes, the conditions for the immune response to develop and the mechanisms that interfere with it. A commented list of the major vaccination trials whose results have been recently, published or are ongoing is also presented. Reasons for failure and potential success are underlined to offer a balanced view of this scientifically exciting but still clinically unrewarding field of investigation.

Original languageEnglish
Pages (from-to)195-207
Number of pages13
JournalExpert Review of Dermatology
Volume3
Issue number2
DOIs
Publication statusPublished - Apr 2008

Keywords

  • Melanoma
  • Melanoma vaccines
  • Melanoma-associated antigens
  • NKG2D
  • T lymphocytes
  • T-cell responses

ASJC Scopus subject areas

  • Dermatology

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