Update on vaccines for melanoma patients

Vincenzo Russo; Cristina Maccalli; Lorenzo Pilla; Santo Raffaele Mercuri; Elena Orsenigo; Sylvain Mukenge; Marco Bregni; Giorgio Parmiani

doi:10.1586/17469872.3.2.195

Update on vaccines for melanoma patients

Vincenzo Russo, Cristina Maccalli, Lorenzo Pilla, Santo Raffaele Mercuri, Elena Orsenigo, Sylvain Mukenge, Marco Bregni, Giorgio Parmiani

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Vaccination against melanoma has a long history but only recently has this therapeutic approach found a reliable scientific rationale. This review summarizes and updates the knowledge on the role of the main players in the vaccination strategy against metastatic melanoma, that is, the melanoma-associated antigens recognized by T and natural killer T lymphocytes, the conditions for the immune response to develop and the mechanisms that interfere with it. A commented list of the major vaccination trials whose results have been recently, published or are ongoing is also presented. Reasons for failure and potential success are underlined to offer a balanced view of this scientifically exciting but still clinically unrewarding field of investigation.

Original language	English
Pages (from-to)	195-207
Number of pages	13
Journal	Expert Review of Dermatology
Volume	3
Issue number	2
DOIs	https://doi.org/10.1586/17469872.3.2.195
Publication status	Published - Apr 2008

Keywords

Melanoma
Melanoma vaccines
Melanoma-associated antigens
NKG2D
T lymphocytes
T-cell responses

ASJC Scopus subject areas

Dermatology

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abstract = "Vaccination against melanoma has a long history but only recently has this therapeutic approach found a reliable scientific rationale. This review summarizes and updates the knowledge on the role of the main players in the vaccination strategy against metastatic melanoma, that is, the melanoma-associated antigens recognized by T and natural killer T lymphocytes, the conditions for the immune response to develop and the mechanisms that interfere with it. A commented list of the major vaccination trials whose results have been recently, published or are ongoing is also presented. Reasons for failure and potential success are underlined to offer a balanced view of this scientifically exciting but still clinically unrewarding field of investigation.",

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AU - Russo, Vincenzo

AU - Maccalli, Cristina

AU - Pilla, Lorenzo

AU - Mercuri, Santo Raffaele

AU - Orsenigo, Elena

AU - Mukenge, Sylvain

AU - Bregni, Marco

AU - Parmiani, Giorgio

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AB - Vaccination against melanoma has a long history but only recently has this therapeutic approach found a reliable scientific rationale. This review summarizes and updates the knowledge on the role of the main players in the vaccination strategy against metastatic melanoma, that is, the melanoma-associated antigens recognized by T and natural killer T lymphocytes, the conditions for the immune response to develop and the mechanisms that interfere with it. A commented list of the major vaccination trials whose results have been recently, published or are ongoing is also presented. Reasons for failure and potential success are underlined to offer a balanced view of this scientifically exciting but still clinically unrewarding field of investigation.

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