Updates in the molecular epidemiology and systemic approaches to penile cancer

Penile cancer is a rare, but increasingly more common diagnosis. Although more there are more cases of penile cancer being diagnosed (the incidence is increasing), mortality (or conversely overall survival) has not changed. A detailed discussion of current treatments, along with potential therapeutic targets, and ongoing clinical trials is presented. This review gives insight to treatment strategies and novel modalities to combat a disease with sparse therapeutic options.