Upper airway volume after Le Fort III advancement in subjects with craniofacial malformation

Giorgio Iannetti, Antonella Polimeni, Marco Pagnoni, Maria Teresa Fadda, Valeria Ranieri, Simona Tecco, Felice Festa

Research output: Contribution to journalArticlepeer-review


Aim: There are no quantitative standards for the volumetric measurements of the airway space after Le Fort III advancement. Computed tomographic (CT) scans have provided the opportunity to compare with the accuracy of real anatomic changes, thus the functional improvements, resulting after a surgical treatment. Materials and Methods: Three-dimensional CT scans processed by Digital Imaging and Communications in Medicine files in Dolphin 3D software were used to assess the airway space volume in 4 subjects affected by craniofacial syndromic malformations treated with Le Fort III advancement. The preoperative (T 0) and postoperative (T1: 6 mo after surgery) three-dimensional craniofacial CT scans of the subjects were collected and retrospectively analyzed. Image segmentation of the anatomic structures of interest and the three-dimensional graphic rendering were done by using the Dolphin Imaging Plus 11.0 software. Results: The airway space volume was significantly increased after surgery (mean [SD]: from 9166.57 [1861.48] mm 3 to 15,300.45 [5114.09] mm3; P <0.01). The sagittal surfaces had an expansion from 798.92 (74.88) to 1151.45 (218.47) mm 2. The coronal surfaces grew from 226.75 (62.85) to 390.42 (102.21) mm2, and axial surfaces increased 473.32 (62.34) to 676.00 (151.07) mm2 from T0 to T1. Conclusions: In conclusion, this study showed an increase in the upper airway space volume in white subjects after Le Fort III advancement.

Original languageEnglish
Pages (from-to)351-355
Number of pages5
JournalJournal of Craniofacial Surgery
Issue number1
Publication statusPublished - Jan 2011


  • airway space volume
  • Apert syndrome
  • Crouzon syndrome
  • Le Fort III
  • midface advancement
  • obstructive sleep apnea syndrome

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery


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