TY - JOUR
T1 - Upper GI endoscopy in elderly patients
T2 - Predictive factors of relevant endoscopic findings
AU - Buri, Luigi
AU - Zullo, Angelo
AU - Hassan, Cesare
AU - Bersani, Gianluca
AU - Anti, Marcello
AU - Bianco, Maria A.
AU - Cipolletta, Livio
AU - Giulio, Emilio Di
AU - Matteo, Giovanni Di
AU - Familiari, Luigi
AU - Ficano, Leonardo
AU - Loriga, Piero
AU - Morini, Sergio
AU - Pietropaolo, Vincenzo
AU - Zambelli, Alessandro
AU - Grossi, Enzo
AU - Tessari, Francesco
AU - Intraligi, Marco
AU - Buscema, Massimo
PY - 2013
Y1 - 2013
N2 - Elderly patients are at increased risk for peptic ulcer and cancer. Predictive factors of relevant endoscopic findings at upper endoscopy in the elderly are unknown. This was a post hoc analysis of a nationwide, endoscopic study. A total of 3,147 elderly patients were selected. Demographic, clinical, and endoscopic data were systematically collected. Relevant findings and new diagnoses of peptic ulcer and malignancy were computed. Both univariate and multivariate analyses were performed. A total of 1,559 (49. 5%), 213 (6. 8%), 93 (3%) relevant findings, peptic ulcers, and malignancies were detected. Peptic ulcers and malignancies were more frequent in >85-year-old patients (OR 3. 1, 95% CI = 2. 0-4. 7, p = 0. 001). The presence of dysphagia (OR = 5. 15), weight loss (OR = 4. 77), persistent vomiting (OR = 3. 68), anaemia (OR = 1. 83), and male gender (OR = 1. 9) were significantly associated with a malignancy, whilst overt bleeding (OR = 6. 66), NSAIDs use (OR = 2. 23), and epigastric pain (OR = 1. 90) were associated with the presence of peptic ulcer. Peptic ulcer or malignancies were detected in 10% of elderly patients, supporting the use of endoscopy in this age group. Very elderly patients appear to be at higher risk of such lesions.
AB - Elderly patients are at increased risk for peptic ulcer and cancer. Predictive factors of relevant endoscopic findings at upper endoscopy in the elderly are unknown. This was a post hoc analysis of a nationwide, endoscopic study. A total of 3,147 elderly patients were selected. Demographic, clinical, and endoscopic data were systematically collected. Relevant findings and new diagnoses of peptic ulcer and malignancy were computed. Both univariate and multivariate analyses were performed. A total of 1,559 (49. 5%), 213 (6. 8%), 93 (3%) relevant findings, peptic ulcers, and malignancies were detected. Peptic ulcers and malignancies were more frequent in >85-year-old patients (OR 3. 1, 95% CI = 2. 0-4. 7, p = 0. 001). The presence of dysphagia (OR = 5. 15), weight loss (OR = 4. 77), persistent vomiting (OR = 3. 68), anaemia (OR = 1. 83), and male gender (OR = 1. 9) were significantly associated with a malignancy, whilst overt bleeding (OR = 6. 66), NSAIDs use (OR = 2. 23), and epigastric pain (OR = 1. 90) were associated with the presence of peptic ulcer. Peptic ulcer or malignancies were detected in 10% of elderly patients, supporting the use of endoscopy in this age group. Very elderly patients appear to be at higher risk of such lesions.
KW - Elderly patients
KW - Malignancy
KW - Peptic ulcer
KW - Predictive factors
KW - Upper endoscopy
UR - http://www.scopus.com/inward/record.url?scp=84874369319&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874369319&partnerID=8YFLogxK
U2 - 10.1007/s11739-011-0598-3
DO - 10.1007/s11739-011-0598-3
M3 - Article
C2 - 21538157
AN - SCOPUS:84874369319
VL - 8
SP - 141
EP - 146
JO - Internal and Emergency Medicine
JF - Internal and Emergency Medicine
SN - 1828-0447
IS - 2
ER -