Upper GI endoscopy in elderly patients: Predictive factors of relevant endoscopic findings

Luigi Buri, Angelo Zullo, Cesare Hassan, Gianluca Bersani, Marcello Anti, Maria A. Bianco, Livio Cipolletta, Emilio Di Giulio, Giovanni Di Matteo, Luigi Familiari, Leonardo Ficano, Piero Loriga, Sergio Morini, Vincenzo Pietropaolo, Alessandro Zambelli, Enzo Grossi, Francesco Tessari, Marco Intraligi, Massimo Buscema

Research output: Contribution to journalArticlepeer-review


Elderly patients are at increased risk for peptic ulcer and cancer. Predictive factors of relevant endoscopic findings at upper endoscopy in the elderly are unknown. This was a post hoc analysis of a nationwide, endoscopic study. A total of 3,147 elderly patients were selected. Demographic, clinical, and endoscopic data were systematically collected. Relevant findings and new diagnoses of peptic ulcer and malignancy were computed. Both univariate and multivariate analyses were performed. A total of 1,559 (49. 5%), 213 (6. 8%), 93 (3%) relevant findings, peptic ulcers, and malignancies were detected. Peptic ulcers and malignancies were more frequent in >85-year-old patients (OR 3. 1, 95% CI = 2. 0-4. 7, p = 0. 001). The presence of dysphagia (OR = 5. 15), weight loss (OR = 4. 77), persistent vomiting (OR = 3. 68), anaemia (OR = 1. 83), and male gender (OR = 1. 9) were significantly associated with a malignancy, whilst overt bleeding (OR = 6. 66), NSAIDs use (OR = 2. 23), and epigastric pain (OR = 1. 90) were associated with the presence of peptic ulcer. Peptic ulcer or malignancies were detected in 10% of elderly patients, supporting the use of endoscopy in this age group. Very elderly patients appear to be at higher risk of such lesions.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalInternal and Emergency Medicine
Issue number2
Publication statusPublished - 2013


  • Elderly patients
  • Malignancy
  • Peptic ulcer
  • Predictive factors
  • Upper endoscopy

ASJC Scopus subject areas

  • Emergency Medicine
  • Internal Medicine


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