Upper motor neuron dysfunction reduces the emg evidence of myasthenia gravis

F. Fiacchino, V. Scaioli, C. Antozzi, A. Giannini

Research output: Contribution to journalArticlepeer-review


Hyposensitivity to the action of nondepolarizing muscle relaxants has been frequently observed in patients with upper motor neuron dysfunction and in patients treated with antiepileptic drugs. To ascertain whether the same conditions are also characterized by a reduced sensitivity to the effects of anti-acetylcholine-receptor antibodies occurring in myasthenia gravis, bilateral investigations of neuromuscular transmission were conducted on proximal and distal muscles of a myasthenic patient with a long history of hemiparesis and epilepsy. It was observed that electromyographic evidence of myasthenia gravis was absent in distal muscles (and low in proximal ones) of the paretic side. Even though the influence of antiepileptic treatment could not be assessed with certainty in this patient, indirect evidence suggests that hyposensitivity to anti-acetylcholine-receptor antibodies is an unlikely consequence of neuromuscular changes induced by anticonvulsants.

Original languageEnglish
Pages (from-to)178-182
Number of pages5
JournalJournal of Neurosurgical Anesthesiology
Issue number3
Publication statusPublished - 1995


  • Acetylcho-line-receptor
  • Anticonvulsant
  • Hemiparesis
  • Myasthenia gravis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology
  • Surgery


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