Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis

Carolina Scagnolari, Fabio Midulla, Simona Trombetti, Alessandra Pierangeli, Valeria Tromba, Rosanna Grossi, Paola Di Marco, Caterina Dianzani, Enrico Girardi, Guido Antonelli

Research output: Contribution to journalArticle

Abstract

To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus-associated respiratory disease in early life.

Original languageEnglish
Pages (from-to)1355-1359
Number of pages5
JournalExperimental Biology and Medicine
Volume232
Issue number10
DOIs
Publication statusPublished - Nov 2007

Keywords

  • 2-5 OAS
  • Bronchiolitis
  • Interferon
  • P56
  • PKR
  • Rhinovirus
  • RSV

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Scagnolari, C., Midulla, F., Trombetti, S., Pierangeli, A., Tromba, V., Grossi, R., Di Marco, P., Dianzani, C., Girardi, E., & Antonelli, G. (2007). Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis. Experimental Biology and Medicine, 232(10), 1355-1359. https://doi.org/10.3181/0705-BC-124