Uptake of glutamate in beagle dogs after oral gavage with MSG

R. W. James, R. Heywood, M. Salmona

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A number of studies were performed in Beagle dogs to assess the clinical, biochemical and histological effects of administering monosodium glutamate (MSG) by oral gavage. Serum glutamate levels were markedly raised irrespective of the dose administered. Vomiting consistently occurred at the time of the serum glutamate peak. There was no difference between control and MSG-treated dogs with regard to glutamate concentration in cerebrospinal fluid (CSF) or brain tissue taken from the region of the third ventricle. MSG did not accumulate in the liver, kidney, duodenum or intestinal fluid of dosed dogs. At the time of peak glutamate concentration there was a relative drop in serum potassium concentration, with a subsequent increase in sodium concentration.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalToxicology Letters
Volume2
Issue number5
DOIs
Publication statusPublished - 1978

Fingerprint

Sodium Glutamate
Glutamic Acid
Dogs
Serum
Cerebrospinal fluid
Third Ventricle
Duodenum
Liver
Vomiting
Cerebrospinal Fluid
Brain
Potassium
Sodium
Tissue
Kidney
Fluids

ASJC Scopus subject areas

  • Toxicology

Cite this

Uptake of glutamate in beagle dogs after oral gavage with MSG. / James, R. W.; Heywood, R.; Salmona, M.

In: Toxicology Letters, Vol. 2, No. 5, 1978, p. 305-311.

Research output: Contribution to journalArticle

James, R. W. ; Heywood, R. ; Salmona, M. / Uptake of glutamate in beagle dogs after oral gavage with MSG. In: Toxicology Letters. 1978 ; Vol. 2, No. 5. pp. 305-311.
@article{2c072a9bcf5a45f5a181888938fdd2f2,
title = "Uptake of glutamate in beagle dogs after oral gavage with MSG",
abstract = "A number of studies were performed in Beagle dogs to assess the clinical, biochemical and histological effects of administering monosodium glutamate (MSG) by oral gavage. Serum glutamate levels were markedly raised irrespective of the dose administered. Vomiting consistently occurred at the time of the serum glutamate peak. There was no difference between control and MSG-treated dogs with regard to glutamate concentration in cerebrospinal fluid (CSF) or brain tissue taken from the region of the third ventricle. MSG did not accumulate in the liver, kidney, duodenum or intestinal fluid of dosed dogs. At the time of peak glutamate concentration there was a relative drop in serum potassium concentration, with a subsequent increase in sodium concentration.",
author = "James, {R. W.} and R. Heywood and M. Salmona",
year = "1978",
doi = "10.1016/0378-4274(78)90030-9",
language = "English",
volume = "2",
pages = "305--311",
journal = "Toxicology Letters",
issn = "0378-4274",
publisher = "Elsevier BV",
number = "5",

}

TY - JOUR

T1 - Uptake of glutamate in beagle dogs after oral gavage with MSG

AU - James, R. W.

AU - Heywood, R.

AU - Salmona, M.

PY - 1978

Y1 - 1978

N2 - A number of studies were performed in Beagle dogs to assess the clinical, biochemical and histological effects of administering monosodium glutamate (MSG) by oral gavage. Serum glutamate levels were markedly raised irrespective of the dose administered. Vomiting consistently occurred at the time of the serum glutamate peak. There was no difference between control and MSG-treated dogs with regard to glutamate concentration in cerebrospinal fluid (CSF) or brain tissue taken from the region of the third ventricle. MSG did not accumulate in the liver, kidney, duodenum or intestinal fluid of dosed dogs. At the time of peak glutamate concentration there was a relative drop in serum potassium concentration, with a subsequent increase in sodium concentration.

AB - A number of studies were performed in Beagle dogs to assess the clinical, biochemical and histological effects of administering monosodium glutamate (MSG) by oral gavage. Serum glutamate levels were markedly raised irrespective of the dose administered. Vomiting consistently occurred at the time of the serum glutamate peak. There was no difference between control and MSG-treated dogs with regard to glutamate concentration in cerebrospinal fluid (CSF) or brain tissue taken from the region of the third ventricle. MSG did not accumulate in the liver, kidney, duodenum or intestinal fluid of dosed dogs. At the time of peak glutamate concentration there was a relative drop in serum potassium concentration, with a subsequent increase in sodium concentration.

UR - http://www.scopus.com/inward/record.url?scp=0018069884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018069884&partnerID=8YFLogxK

U2 - 10.1016/0378-4274(78)90030-9

DO - 10.1016/0378-4274(78)90030-9

M3 - Article

VL - 2

SP - 305

EP - 311

JO - Toxicology Letters

JF - Toxicology Letters

SN - 0378-4274

IS - 5

ER -