Uptake of [N-methyl-11C]propionyl-L-carnitine (PLC) in human myocardium

V. J. Cunningham, S. D. Rosen, H. Boyd, S. Osman, R. J. Davenport, R. N. Gunn, V. W. Pike, P. G. Camici

Research output: Contribution to journalArticle

Abstract

We studied the uptake of propionyl-L-carnitine from plasma by the myocardium in 10 human subjects using positron emission tomography. Propionyl-L-carnitine was labeled in the N-methyl position with carbon-11 (T 1/4 = 20.4 min) and administered i.v. in trace amounts. The uptake of the radiolabel by the myocardium was then scanned over a period of 1 1/4 h. The activity-time course of the tracer in blood and plasma and the exchange of the label in plasma between propionyl carnitine, acetyl carnitine and free carnitine was followed during the scans. Myocardial blood flow was also measured in the same subjects. The results show an exchange of the tracer between the myocardium and plasma, and they show an apparently irreversible component of uptake, a result consistent with the incorporation of the label into relatively large intracellular carnitine pools.

Original languageEnglish
Pages (from-to)511-517
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume277
Issue number1
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Pharmacology

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