Uptake-release by MSCs of a cationic platinum(II) complex active in vitro on human malignant cancer cell lines

I. Rimoldi, V. Coccè, G. Facchetti, G. Alessandri, A.T. Brini, F. Sisto, E. Parati, L. Cavicchini, G. Lucchini, F. Petrella, E. Ciusani, A. Pessina

Research output: Contribution to journalArticle

Abstract

In this study, the in vitro stability of cisplatin (CisPt) and cationic platinum(II)-complex (caPt(II)-complex) and their in vitro activity (antiproliferative and anti-angiogenic properties) were investigated against three aggressive human tumor cell lines. caPt(II)-complex shown a high stability until 9 days of treatment and displayed a significant and higher activity than CisPt against both NCI-H28 mesothelioma (19.37 ± 9.57 μM versus 34.66 ± 7.65 μM for CisPt) and U87 MG glioblastoma (19.85 ± 0.97 μM versus 54.14 ± 3.19 for CisPt). Mesenchymal Stromal Cells (AT-MSCs) showed a significant different sensitivity (IC50 = 71.9 ± 15.1 μM for caPt(II)-complex and 8.7 ± 4.5 μM for CisPt) to the antiproliferative activity of caPt(II)-complex and CisPt. The ability of MSCs to uptake both the drugs in a similar amount of 2.49 pM /cell, suggested a possible development of new therapies based on cell mediated drug delivery. © 2018 Elsevier Masson SAS
Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalBiomedicine and Pharmacotherapy
Volume108
DOIs
Publication statusPublished - 2018

Keywords

  • Cationic platinum (II)-complex
  • Cisplatin
  • Drug delivery
  • Glioblastoma
  • Mesenchymal stromal cells
  • Mesothelioma
  • cation
  • cisplatin
  • paclitaxel
  • platinum complex
  • adipose tissue
  • antiangiogenic activity
  • antineoplastic activity
  • antiproliferative activity
  • Article
  • cell lysate
  • cell proliferation
  • cell viability
  • CFPAC-1 cell line
  • chemosensitivity
  • concentration response
  • controlled study
  • drug cytotoxicity
  • drug delivery system
  • drug release
  • drug stability
  • drug uptake
  • glioblastoma
  • human
  • human cell
  • HUVEC cell line
  • IC50
  • in vitro study
  • mesenchymal stroma cell
  • NCI-H28 cell line
  • pancreas adenocarcinoma
  • pleura mesothelioma
  • priority journal
  • U-87MG ATCC cell line

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