Urgency degree and bladder contraction velocity: Sequential changes in women with idiopathic detrusor overactivity

A. Cucchi, S. Quaglini, S. Siracusano, B. Rovereto

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aims: In patients with idiopathic detrusor overactivity (DO) who showed storage symptoms worsening with time, we checked whether and which urodynamic parameter changes are associated with an increased urgency degree. Materials and Methods: We analyzed retrospectively the urodynamic findings in 54 women -27 with storage symptoms (Group A, mean age 32 ± 7 years) and 27 controls, (Group B, mean age 30 ± 9 years). These latter had a history of recurrent UTIs (urinary tract infections), but when seen by us had no UTI, DO, lower urinary tract symptoms, or any other pathological finding. Group A had a first urodynamic examination when first referred (time 1) and were re-assessed a mean of 16 months later (time 2) for worsened storage symptoms. Results: In Group A, an idiopathic DO was shown at both times 1 and 2; urgency of voiding could be delayed during cystometry for ≥2 min (= moderate urgency) at time 1 and for ≤2 min (= severe urgency) at time 2; detrusor contraction strength or contractility proved higher than in Group B (P <0.001) and increased from time 1 to time 2 (P <0.001), detrusor shortening velocity being always the major component of the higher contractility levels. Conclusions: A DO-related increase in bladder contractility may have been further enhanced by severe urgency through a positive feedback mechanism. The urgency degree proved closely associated in DO patients with the level of detrusor shortening velocity rather than with detrusor pressure.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalNeurourology and Urodynamics
Volume25
Issue number2
DOIs
Publication statusPublished - 2006

Fingerprint

Urinary Bladder
Urodynamics
Urinary Tract Infections
Lower Urinary Tract Symptoms
Pressure
Control Groups

Keywords

  • Bladder
  • Detrusor contractility
  • Detrusor overactivity
  • Urgency of voiding
  • Urodynamics

ASJC Scopus subject areas

  • Clinical Neurology
  • Nephrology
  • Urology

Cite this

Urgency degree and bladder contraction velocity : Sequential changes in women with idiopathic detrusor overactivity. / Cucchi, A.; Quaglini, S.; Siracusano, S.; Rovereto, B.

In: Neurourology and Urodynamics, Vol. 25, No. 2, 2006, p. 123-127.

Research output: Contribution to journalArticle

@article{8190f29c8d5f48f29d9feca5ffb742a4,
title = "Urgency degree and bladder contraction velocity: Sequential changes in women with idiopathic detrusor overactivity",
abstract = "Aims: In patients with idiopathic detrusor overactivity (DO) who showed storage symptoms worsening with time, we checked whether and which urodynamic parameter changes are associated with an increased urgency degree. Materials and Methods: We analyzed retrospectively the urodynamic findings in 54 women -27 with storage symptoms (Group A, mean age 32 ± 7 years) and 27 controls, (Group B, mean age 30 ± 9 years). These latter had a history of recurrent UTIs (urinary tract infections), but when seen by us had no UTI, DO, lower urinary tract symptoms, or any other pathological finding. Group A had a first urodynamic examination when first referred (time 1) and were re-assessed a mean of 16 months later (time 2) for worsened storage symptoms. Results: In Group A, an idiopathic DO was shown at both times 1 and 2; urgency of voiding could be delayed during cystometry for ≥2 min (= moderate urgency) at time 1 and for ≤2 min (= severe urgency) at time 2; detrusor contraction strength or contractility proved higher than in Group B (P <0.001) and increased from time 1 to time 2 (P <0.001), detrusor shortening velocity being always the major component of the higher contractility levels. Conclusions: A DO-related increase in bladder contractility may have been further enhanced by severe urgency through a positive feedback mechanism. The urgency degree proved closely associated in DO patients with the level of detrusor shortening velocity rather than with detrusor pressure.",
keywords = "Bladder, Detrusor contractility, Detrusor overactivity, Urgency of voiding, Urodynamics",
author = "A. Cucchi and S. Quaglini and S. Siracusano and B. Rovereto",
year = "2006",
doi = "10.1002/nau.20217",
language = "English",
volume = "25",
pages = "123--127",
journal = "Neurourology and Urodynamics",
issn = "0733-2467",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Urgency degree and bladder contraction velocity

T2 - Sequential changes in women with idiopathic detrusor overactivity

AU - Cucchi, A.

AU - Quaglini, S.

AU - Siracusano, S.

AU - Rovereto, B.

PY - 2006

Y1 - 2006

N2 - Aims: In patients with idiopathic detrusor overactivity (DO) who showed storage symptoms worsening with time, we checked whether and which urodynamic parameter changes are associated with an increased urgency degree. Materials and Methods: We analyzed retrospectively the urodynamic findings in 54 women -27 with storage symptoms (Group A, mean age 32 ± 7 years) and 27 controls, (Group B, mean age 30 ± 9 years). These latter had a history of recurrent UTIs (urinary tract infections), but when seen by us had no UTI, DO, lower urinary tract symptoms, or any other pathological finding. Group A had a first urodynamic examination when first referred (time 1) and were re-assessed a mean of 16 months later (time 2) for worsened storage symptoms. Results: In Group A, an idiopathic DO was shown at both times 1 and 2; urgency of voiding could be delayed during cystometry for ≥2 min (= moderate urgency) at time 1 and for ≤2 min (= severe urgency) at time 2; detrusor contraction strength or contractility proved higher than in Group B (P <0.001) and increased from time 1 to time 2 (P <0.001), detrusor shortening velocity being always the major component of the higher contractility levels. Conclusions: A DO-related increase in bladder contractility may have been further enhanced by severe urgency through a positive feedback mechanism. The urgency degree proved closely associated in DO patients with the level of detrusor shortening velocity rather than with detrusor pressure.

AB - Aims: In patients with idiopathic detrusor overactivity (DO) who showed storage symptoms worsening with time, we checked whether and which urodynamic parameter changes are associated with an increased urgency degree. Materials and Methods: We analyzed retrospectively the urodynamic findings in 54 women -27 with storage symptoms (Group A, mean age 32 ± 7 years) and 27 controls, (Group B, mean age 30 ± 9 years). These latter had a history of recurrent UTIs (urinary tract infections), but when seen by us had no UTI, DO, lower urinary tract symptoms, or any other pathological finding. Group A had a first urodynamic examination when first referred (time 1) and were re-assessed a mean of 16 months later (time 2) for worsened storage symptoms. Results: In Group A, an idiopathic DO was shown at both times 1 and 2; urgency of voiding could be delayed during cystometry for ≥2 min (= moderate urgency) at time 1 and for ≤2 min (= severe urgency) at time 2; detrusor contraction strength or contractility proved higher than in Group B (P <0.001) and increased from time 1 to time 2 (P <0.001), detrusor shortening velocity being always the major component of the higher contractility levels. Conclusions: A DO-related increase in bladder contractility may have been further enhanced by severe urgency through a positive feedback mechanism. The urgency degree proved closely associated in DO patients with the level of detrusor shortening velocity rather than with detrusor pressure.

KW - Bladder

KW - Detrusor contractility

KW - Detrusor overactivity

KW - Urgency of voiding

KW - Urodynamics

UR - http://www.scopus.com/inward/record.url?scp=33644899426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644899426&partnerID=8YFLogxK

U2 - 10.1002/nau.20217

DO - 10.1002/nau.20217

M3 - Article

C2 - 16381021

AN - SCOPUS:33644899426

VL - 25

SP - 123

EP - 127

JO - Neurourology and Urodynamics

JF - Neurourology and Urodynamics

SN - 0733-2467

IS - 2

ER -