TY - JOUR
T1 - Uric acid and survival in chronic heart
T2 - Failure validation and application in metabolic, functional, and hemodynamic staging
AU - Anker, Stefan D.
AU - Doehner, Wolfram
AU - Rauchhaus, Mathias
AU - Sharma, Rakesh
AU - Francis, Darrel
AU - Knosalla, Christoph
AU - Davos, Constantinos H.
AU - Cicoira, Mariantonietta
AU - Shamim, Waqar
AU - Kemp, Michel
AU - Segal, Robert
AU - Osterziel, Karl Josef
AU - Leyva, Francisco
AU - Hetzer, Roland
AU - Ponikowski, Piotr
AU - Coats, Andrew J S
PY - 2003/4/22
Y1 - 2003/4/22
N2 - Background - Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF). Methods and Results - For the derivation study, 112 patients with CHF (age 59±12 years, peak oxygen consumption [V̇o2] 17±7 mL/kg per minute) were recruited. In separate studies, we validated the prognostic value of UA (n=182) and investigated the relationship between MFH score and the decision to list patients for heart transplantation (n=120). In the derivation study, the best mortality predicting UA cutoff (at 12 months) was 565 μmol/L (9.50 mg/dL) (independently of age, peak V̇o2, left ventricular ejection fraction, diuretic dose, sodium, creatinine, and urea; P2 ≤14 mL/kg per min (MFH score 3), 12-month survival was lowest (31%) compared with patients with 2 (64%), 1 (77%), or no (98%, P
AB - Background - Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF). Methods and Results - For the derivation study, 112 patients with CHF (age 59±12 years, peak oxygen consumption [V̇o2] 17±7 mL/kg per minute) were recruited. In separate studies, we validated the prognostic value of UA (n=182) and investigated the relationship between MFH score and the decision to list patients for heart transplantation (n=120). In the derivation study, the best mortality predicting UA cutoff (at 12 months) was 565 μmol/L (9.50 mg/dL) (independently of age, peak V̇o2, left ventricular ejection fraction, diuretic dose, sodium, creatinine, and urea; P2 ≤14 mL/kg per min (MFH score 3), 12-month survival was lowest (31%) compared with patients with 2 (64%), 1 (77%), or no (98%, P
KW - Heart failure
KW - Hemodynamics
KW - Prognosis
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U2 - 10.1161/01.CIR.0000065637.10517.A0
DO - 10.1161/01.CIR.0000065637.10517.A0
M3 - Article
C2 - 12707250
AN - SCOPUS:0037461111
VL - 107
SP - 1991
EP - 1997
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 15
ER -