Uric acid and survival in chronic heart: Failure validation and application in metabolic, functional, and hemodynamic staging

Stefan D. Anker, Wolfram Doehner, Mathias Rauchhaus, Rakesh Sharma, Darrel Francis, Christoph Knosalla, Constantinos H. Davos, Mariantonietta Cicoira, Waqar Shamim, Michel Kemp, Robert Segal, Karl Josef Osterziel, Francisco Leyva, Roland Hetzer, Piotr Ponikowski, Andrew J S Coats

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF). Methods and Results - For the derivation study, 112 patients with CHF (age 59±12 years, peak oxygen consumption [V̇o2] 17±7 mL/kg per minute) were recruited. In separate studies, we validated the prognostic value of UA (n=182) and investigated the relationship between MFH score and the decision to list patients for heart transplantation (n=120). In the derivation study, the best mortality predicting UA cutoff (at 12 months) was 565 μmol/L (9.50 mg/dL) (independently of age, peak V̇o2, left ventricular ejection fraction, diuretic dose, sodium, creatinine, and urea; P2 ≤14 mL/kg per min (MFH score 3), 12-month survival was lowest (31%) compared with patients with 2 (64%), 1 (77%), or no (98%, P

Original languageEnglish
Pages (from-to)1991-1997
Number of pages7
JournalCirculation
Volume107
Issue number15
DOIs
Publication statusPublished - Apr 22 2003

Keywords

  • Heart failure
  • Hemodynamics
  • Prognosis

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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