TY - JOUR
T1 - Uric acid in chronic heart failure
T2 - A measure of the anaerobic threshold
AU - Leyva, F.
AU - Chua, T. P.
AU - Anker, S. D.
AU - Poole-Wilson, P. A.
AU - Coats, A. J.
PY - 1998/5
Y1 - 1998/5
N2 - Background: The anaerobic threshold (AT) is a measure of the balance between aerobic and anaerobic cellular metabolism. Hyperuricemia occurs in conditions which involve an imbalance between cellular oxygen consumption and carbon dioxide production, such as chronic heart failure (CHF). We therefore hypothesised that in CHF, serum uric acid might be related to the AT. Methods: Patients with CHF [n=40, aged 58.7±1.9, New York Heart Association Class I-IV, maximal oxygen consumption (MVO2)=18.7±01.1 ml/kg/min, left ventricular ejection fraction = 26±2 %] and 10 age-matched healthy controls underwent measurement of serum uric acid at rest and assessment of AT. This was derived from MVO2 and the regression slope relating minute ventilation to carbon dioxide output (VE-VCO2) during a maximal treadmill exercise test. Results: Compared to healthy controls, patients with CHF had a lower AT (11.8±0.7 v 16.9±1.1 ml/kg/min, p2 = 0.31, p2 = 0.31, p
AB - Background: The anaerobic threshold (AT) is a measure of the balance between aerobic and anaerobic cellular metabolism. Hyperuricemia occurs in conditions which involve an imbalance between cellular oxygen consumption and carbon dioxide production, such as chronic heart failure (CHF). We therefore hypothesised that in CHF, serum uric acid might be related to the AT. Methods: Patients with CHF [n=40, aged 58.7±1.9, New York Heart Association Class I-IV, maximal oxygen consumption (MVO2)=18.7±01.1 ml/kg/min, left ventricular ejection fraction = 26±2 %] and 10 age-matched healthy controls underwent measurement of serum uric acid at rest and assessment of AT. This was derived from MVO2 and the regression slope relating minute ventilation to carbon dioxide output (VE-VCO2) during a maximal treadmill exercise test. Results: Compared to healthy controls, patients with CHF had a lower AT (11.8±0.7 v 16.9±1.1 ml/kg/min, p2 = 0.31, p2 = 0.31, p
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M3 - Article
AN - SCOPUS:33751413597
VL - 79
JO - Heart
JF - Heart
SN - 1355-6037
IS - SUPPL. 1
ER -