Uric acid in chronic heart failure: A measure of the anaerobic threshold

F. Leyva, T. P. Chua, S. D. Anker, P. A. Poole-Wilson, A. J. Coats

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The anaerobic threshold (AT) is a measure of the balance between aerobic and anaerobic cellular metabolism. Hyperuricemia occurs in conditions which involve an imbalance between cellular oxygen consumption and carbon dioxide production, such as chronic heart failure (CHF). We therefore hypothesised that in CHF, serum uric acid might be related to the AT. Methods: Patients with CHF [n=40, aged 58.7±1.9, New York Heart Association Class I-IV, maximal oxygen consumption (MVO2)=18.7±01.1 ml/kg/min, left ventricular ejection fraction = 26±2 %] and 10 age-matched healthy controls underwent measurement of serum uric acid at rest and assessment of AT. This was derived from MVO2 and the regression slope relating minute ventilation to carbon dioxide output (VE-VCO2) during a maximal treadmill exercise test. Results: Compared to healthy controls, patients with CHF had a lower AT (11.8±0.7 v 16.9±1.1 ml/kg/min, p2 = 0.31, p2 = 0.31, p

Original languageEnglish
JournalHeart
Volume79
Issue numberSUPPL. 1
Publication statusPublished - May 1998

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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