TY - JOUR
T1 - Uric acid in the acute phase of ST elevation myocardial infarction submitted to primary PCI
T2 - Its prognostic role and relation with inflammatory markers. A single center experience
AU - Lazzeri, Chiara
AU - Valente, Serafina
AU - Chiostri, Marco
AU - Sori, Andrea
AU - Bernardo, Pasquale
AU - Gensini, Gian Franco
PY - 2010/1/21
Y1 - 2010/1/21
N2 - Background and methods: Scarce data are available on the prognostic role of uric acid (UA ) in patients with ST elevation myocardial infarction (STEMI). We aimed at assessing the relation between uric acid, measured on Intensive Cardiac Care Unit (ICCU) admission, and mortality at short term follow-up in 466 consecutive STEMI patients submitted to percutaneous coronary intervention (PCI), as well as its relation with inflammatory markers (C-reactive protein, CRP-fibrinogen, erythrocyte sedimentation rate ESR). Results: Higher UA were detectable in the 21.5%.. In-hospital mortality was higher in patients with elevated UA (p <0.01 O.R. (95% C.I.): 3.9 (1.5-10.2)). At backward stepwise regression analysis UA resulted an independent predictor for in-hospital mortality (OR 1.82, 95%CI 1.15-2.86; p = 0.01). Conclusion: Our data strongly suggest that in the acute phase of STEMI patients submitted to PCI, uric acid holds a prognostic role for in-hospital mortality.
AB - Background and methods: Scarce data are available on the prognostic role of uric acid (UA ) in patients with ST elevation myocardial infarction (STEMI). We aimed at assessing the relation between uric acid, measured on Intensive Cardiac Care Unit (ICCU) admission, and mortality at short term follow-up in 466 consecutive STEMI patients submitted to percutaneous coronary intervention (PCI), as well as its relation with inflammatory markers (C-reactive protein, CRP-fibrinogen, erythrocyte sedimentation rate ESR). Results: Higher UA were detectable in the 21.5%.. In-hospital mortality was higher in patients with elevated UA (p <0.01 O.R. (95% C.I.): 3.9 (1.5-10.2)). At backward stepwise regression analysis UA resulted an independent predictor for in-hospital mortality (OR 1.82, 95%CI 1.15-2.86; p = 0.01). Conclusion: Our data strongly suggest that in the acute phase of STEMI patients submitted to PCI, uric acid holds a prognostic role for in-hospital mortality.
KW - Acute myocardial infarction
KW - Angioplasty
KW - Intensive cardiac care
KW - Uric acid
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U2 - 10.1016/j.ijcard.2008.06.024
DO - 10.1016/j.ijcard.2008.06.024
M3 - Article
C2 - 18684529
AN - SCOPUS:73649149434
VL - 138
SP - 206
EP - 209
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 2
ER -