Uric acid in the acute phase of ST elevation myocardial infarction submitted to primary PCI: Its prognostic role and relation with inflammatory markers. A single center experience

Chiara Lazzeri, Serafina Valente, Marco Chiostri, Andrea Sori, Pasquale Bernardo, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review

Abstract

Background and methods: Scarce data are available on the prognostic role of uric acid (UA ) in patients with ST elevation myocardial infarction (STEMI). We aimed at assessing the relation between uric acid, measured on Intensive Cardiac Care Unit (ICCU) admission, and mortality at short term follow-up in 466 consecutive STEMI patients submitted to percutaneous coronary intervention (PCI), as well as its relation with inflammatory markers (C-reactive protein, CRP-fibrinogen, erythrocyte sedimentation rate ESR). Results: Higher UA were detectable in the 21.5%.. In-hospital mortality was higher in patients with elevated UA (p <0.01 O.R. (95% C.I.): 3.9 (1.5-10.2)). At backward stepwise regression analysis UA resulted an independent predictor for in-hospital mortality (OR 1.82, 95%CI 1.15-2.86; p = 0.01). Conclusion: Our data strongly suggest that in the acute phase of STEMI patients submitted to PCI, uric acid holds a prognostic role for in-hospital mortality.

Original languageEnglish
Pages (from-to)206-209
Number of pages4
JournalInternational Journal of Cardiology
Volume138
Issue number2
DOIs
Publication statusPublished - Jan 21 2010

Keywords

  • Acute myocardial infarction
  • Angioplasty
  • Intensive cardiac care
  • Uric acid

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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