Absorption of topical corticosteroids produces systemic effects detectable by determination of plasma ACTH, cortisol, and its metabolites. As previously reported, the 24-hour urinary hydroxycorticoids (17OHCS) determination is a simple and sensitive index of adrenal suppression. A study of the 17OHCS level in 30 psoriatic out-patients using topical corticosteroids was conducted. Results showed a significant decrease in the 17OHCS levels in patients treated with more than 90 g/week of potent or very potent corticosteroid preparations. A comparison of these findings and our data obtained in psoriatic in-patients treated under supervised conditions is also included.
|Number of pages||4|
|Issue number||SUPPL. 113|
|Publication status||Published - 1984|
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